血清sFlt-1、ADAM10对妊娠期高血压孕妇妊娠结局的预测价值  

Predictive value of serum sFlt-1 and ADAM10 on pregnancy outcomes in pregnant women with hypertensive disorder complicating pregnancy

作　　者：邹纯 陈迎 谢茂华 ZOU Chun;CHEN Ying;XIE Maohua(Department of Obstetrics,Wuhan Third Hospital,Wuhan,Hubei 430060,China;Department of Children′s Health,Wuhan Third Hospital,Wuhan,Hubei 430060,China;Department of Obstetrics and Gynecology,Wuhan Third Hospital,Wuhan,Hubei 430060,China)

机构地区：[1]湖北省武汉市第三医院产科,湖北武汉430060 [2]湖北省武汉市第三医院儿童保健科,湖北武汉430060 [3]湖北省武汉市第三医院妇产科,湖北武汉430060

出　　处：《检验医学与临床》2024年第24期3637-3641,共5页Laboratory Medicine and Clinic

基　　金：湖北省卫生健康委员会2019年度第一批联合基金立项项目(WJ2019H206)。

摘　　要：目的探讨妊娠期高血压孕妇血清可溶性fms样酪氨酸激酶1(sFlt-1)、解整合素-金属蛋白酶10(ADAM10)对妊娠结局的预测价值。方法选取2021年1月至2023年1月在该院就诊的106例妊娠期高血压孕妇作为研究组,并根据妊娠结局将患者分为妊娠结局良好组和妊娠结局不良组,另选取同期在该院进行健康体检的孕妇100例作为对照组。采用酶联免疫吸附试验(ELISA)检测血清sFlt-1、ADAM10水平;比较妊娠结局良好组和妊娠结局不良组的临床资料、血清sFlt-1及ADAM10水平;采用多因素Logistic回归分析妊娠期高血压孕妇发生不良妊娠结局的影响因素。结果与对照组相比,研究组血清sFlt-1、ADAM10水平均明显升高,差异均有统计学意义(P<0.05)。106例妊娠期高血压患者分为妊娠结局良好组59例,妊娠结局不良组47例。妊娠结局不良组的年龄、分娩孕周、孕前体质量指数(BMI)、血红蛋白、舒张压、空腹血糖、血肌酐、尿素氮、分娩方式与妊娠结局良好组比较,差异均无统计学意义(P>0.05);妊娠结局不良组孕妇收缩压高于妊娠结局良好组,中重度妊娠期高血压患者例数多于妊娠结局良好组,差异均有统计学意义(P<0.05)。与妊娠结局良好组比较,妊娠结局不良组血清sFlt-1、ADAM10水平均明显升高,差异均有统计学意义(P<0.05)。中重度妊娠期高血压、收缩压升高、血清ADAM10水平升高、sFlt-1水平升高均为妊娠期高血压孕妇发生不良妊娠结局的独立危险因素(P<0.05)。血清ADAM10、sFlt-1单独及联合检测预测妊娠期高血压孕妇发生不良妊娠结局的曲线下面积(AUC)分别为0.894、0.881、0.953,二者联合检测预测的AUC明显大于sFlt-1、ADAM10单独检测的AUC(Z=2.381、2.260,P=0.017、0.024)。结论妊娠期高血压孕妇血清sFlt-1、ADAM10水平对不良妊娠结局的发生具有较高预测效能,且二者联合检测的预测效果更优。Objective To explore the predictive value of serum soluble FMS-like tyrosine kinase-1(sFlt-1)and disintegrin-metalloproteinase 10(ADAM10)levels in pregnant women with hypertensive disorder complicating pregnancy on pregnancy outcome.Methods A total of 106 pregnant women with gestational hypertension in Wuhan Third Hospital from January 2021 to January 2023 were selected as the study group,and the patients were divided into the good pregnancy outcome group and the poor pregnancy outcome group according to the pregnancy outcome,and 100 pregnant women who underwent physical examination in Wuhan Third Hospital during the same period were selected as the control group.The serum levels of sFlt-1 and ADAM10 were detected by enzyme linked immunosorbent assay(ELISA).The clinical data,serum levels of sFlt-1 and ADAM10 were compared between the good pregnancy outcome group and the poor pregnancy outcome group.Multivariate Logistic regression was used to analyze the influencing factors of adverse pregnancy outcomes in pregnant women with gestational hypertension.Results Compared with those in the control group,the serum levels of sFlt-1 and ADAM10 in the study group increased significantly,the differences were statistically significant(P<0.05).The 106 patients were divided as 59 cases in the good pregnancy outcome group and 47 cases in the poor pregnancy outcome group.There was no significant difference on age,delivery gestational week,pre pregnancy body mass index(BMI),hemoglobin,diastolic blood pressure,fasting blood glucose,serum creatinine,urea nitrogen and delivery mode between the poor pregnancy outcome group and the good pregnancy outcome group(P>0.05).The systolic blood pressure in the poor pregnancy outcome group was higher than that in the good pregnancy outcome group,and the number of moderate to severe patients of gestational hypertension was more than that in the good pregnancy outcome group,the differences were statistically significant(P<0.05).Compared with those in the good pregnancy outcome group,the serum l

关 键 词：妊娠期高血压 可溶性fms样酪氨酸激酶1 解整合素-金属蛋白酶10 妊娠结局 预测效能 

分 类 号：R446.9[医药卫生—诊断学]