维生素D、甲状腺激素及微量元素与儿童单纯性肥胖程度的相关性分析  

The correlations between vitamin D,thyroid hormone,trace elements and the degree of childhood simple obesity

作　　者：李小妹[1] 潘慧敏 陈畅 梁摄 LI Xiaomei;PAN Huimin;CHEN Chang;LIANG She(Department of Blood Transfusion,Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital,Nanning,Guangxi 530002,China;Department of Clinical Laboratory,Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital,Nanning,Guangxi 530002,China;Department of Child Healthcare,Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital,Nanning,Guangxi 530002,China)

机构地区：[1]广西壮族自治区妇幼保健院输血科,广西南宁530002 [2]广西壮族自治区妇幼保健院检验科,广西南宁530002 [3]广西壮族自治区妇幼保健院儿保科,广西南宁530002

出　　处：《检验医学与临床》2024年第24期3653-3656,共4页Laboratory Medicine and Clinic

基　　金：广西卫生健康委员会自筹经费科研项目(Z20180092)。

摘　　要：目的探讨维生素D、甲状腺激素及微量元素与儿童单纯性肥胖程度的相关性。方法选取2016年7月至2023年4月就诊于该院儿保科的单纯性肥胖儿童128例为单纯性肥胖组,另选取131例同期体质量指数(BMI)正常的健康体检儿童为对照组。检测两组研究对象维生素D(VitD)、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺素(TSH)、钙(Ca)、铁(Fe)、锌(Zn),比较两组VitD、FT_(3)、FT_(4)、TSH、Ca、Fe、Zn水平。将单纯性肥胖儿童根据BMI分为轻度肥胖组41例,中度肥胖组57例,重度肥胖组30例。分析VitD、FT_(3)、FT_(4)、TSH、Ca、Fe、Zn与儿童单纯性肥胖程度的相关性,采用有序Logistic回归分析肥胖程度的影响因素。结果单纯性肥胖组与对照组性别、年龄、Ca、Fe、Zn及FT_(4)比较,差异均无统计学意义(P>0.05);单纯性肥胖组BMI、FT_(3)、TSH水平高于对照组,VitD水平低于对照组,差异均有统计学意义(P<0.05)。FT_(3)、TSH水平与儿童单纯性肥胖程度呈正相关(r=0.299、0.138,P<0.05),VitD水平与儿童单纯性肥胖程度呈负相关(r=-0.342,P<0.05)。VitD缺乏是儿童单纯性肥胖程度加重的危险因素(OR=2.910,95%CI:1.235~6.859,P<0.05)。结论VitD、FT_(3)、TSH与儿童单纯性肥胖程度具有相关性;VitD缺乏是儿童单纯性肥胖程度加重的危险因素。Objective To explore the correlations between vitamin D,thyroid hormone,trace elements and simple obesity degree in children.Methods A total of 128 children with simple obesity who were treated in the Department of Child Healthcare in Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital from July 2016 to April 2023 were selected as the simple obesity group,and 131 healthy children with normal body mass index(BMI)were selected as the control group.The levels of vitamin D(VitD),free triiodothyronine(FT_(3)),free thyroxine(FT_(4)),thyroid stimulating hormone(TSH),calcium(Ca),iron(Fe)and zinc(Zn)in the two groups were detected,and the levels of VitD,FT_(3),FT_(4),TSH,Ca,Fe and Zn in the two groups were compared.Children with simple obesity were divided into mild obesity group of 41 cases,moderate obesity group of 57 cases,and severe obesity group of 30 cases based on BMI.The correlations between VitD,FT_(3),FT_(4),TSH,Ca,Fe,Zn and the degree of simple obesity in children were analyzed,as well as the influencing factors of the degree of obesity.Results There was no significant difference in gender,age,Ca,Fe,Zn and FT_(4) between the simple obesity group and the control group(P>0.05).The BMI,FT_(3),TSH in the simple obesity group were significant higher than those in the control group,while VitD in the simple obesity group was significant lower than that in the control group(P<0.05).FT_(3) and TSH levels correlated positively with the degree of simple obesity in children(r=0.299,0.138,P<0.05),while VitD level correlated negatively with the degree of simple obesity in children(r=-0.342,P<0.05).Vitamin D deficiency was a risk factor for the aggravation of simple obesity in children(OR=2.910,95%CI:1.235-6.859,P<0.05).Conclusion VitD,FT_(3) and TSH correlate with the degree of simple obesity in children.VitD deficiency is a risk factor for the aggravation of children simple obesity.

关 键 词：儿童 肥胖 维生素D 甲状腺激素 微量元素 

分 类 号：R446.9[医药卫生—诊断学]