益气养心活血汤联合厄贝沙坦氢氯噻嗪对气虚血瘀证慢性心力衰竭患者心肺功能、血清羟脯氨酸水平及心室重构的影响  

Effects of Yiqi Yangxin Huoxue decoction combined with Irbesartan hydrochlorothiazide on cardiopulmonary function,serum hydroxyproline level and ventricular remodeling in patients with chronic heart failure syndrome of Qi deficiency and blood stasis syndrome

作　　者：程伟 谢继宏 陈艳俏 CHENG Wei;XIE Jihong;CHEN Yanqiao(Department of Cardiovascular,Huairou District Traditional Chinese Medicine Hospital in Beijing,Beijing 101400,China)

机构地区：[1]北京市怀柔区中医医院心血管科,北京101400

出　　处：《检验医学与临床》2024年第24期3730-3734,共5页Laboratory Medicine and Clinic

摘　　要：目的分析益气养心活血汤联合厄贝沙坦氢氯噻嗪对气虚血瘀证慢性心力衰竭(CHF)患者心肺功能、血清羟脯氨酸(HYP)水平及心室重构的影响。方法选取2021年1月至2022年1月该院收治的80例CHF患者为研究对象,按照随机数字表法分为观察组和对照组,每组40例。观察组采用益气养阴活血汤联合厄贝沙坦氢氯噻嗪进行治疗,对照组采用安慰剂和厄贝沙坦氢氯噻嗪进行治疗,比较两组中医证候积分、心肺功能指标、心室重构相关指标、HYP水平和不良反应发生率。结果治疗前,两组中医证候积分、心肺功能指标、心室重构相关指标、HYP水平比较,差异均无统计学意义(P>0.05)。治疗后,两组水肿、呼吸困难、面色晦暗中医证候积分均降低,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗后,两组左心室射血分数(LVEF)、呼气峰值流速(PEF)、肺总量(TLC)和第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)均升高,左心室舒张末期内径(LVEDD)均降低,且观察组的LVEF、PEF、TLC、FEV1/FVC高于对照组,LVEDD低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组左心室后壁厚度(LVPW)、室间隔厚度(IVS)、左心室质量指数(LVMW)、左心室后壁收缩末期厚度(PWS)、左心室后壁舒张末期厚度(PWD)均降低,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗后,两组HYP水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05);观察组和对照组不良反应发生率分别为12.50%、22.50%,差异无统计学意义(P>0.05)。结论益气养心活血汤联合厄贝沙坦氢氯噻嗪能够有效提高气虚血瘀证CHF患者的心肺功能,降低HYP水平,抑制心室重构。Objective To analyze the effects of Yiqi Yangxin Huoxue decoction combined with Irbesartan hydrochlorothiazide on cardiopulmonary function,serum hydroxyproline(HYP)level and ventricular remodeling in patients with chronic heart failure(CHF)due to Qi deficiency and blood stasis syndrome.Methods A total of 80 CHF patients admitted to Huairou District Traditional Chinese Medicine Hospital in Beijing from January 2021 to January 2022 were selected as the research subjects.They were randomly divided into observation group and control group using a random number table method,with 40 patients in each group.The observation group was treated with Yiqi Yangxin Huoxue decoction and Irbesartan hydrochlorothiazide,while the control group was treated with placebo and Irbesartan hydrochlorothiazide.The TCM syndrome scores,cardiopulmonary function indicators,ventricular remodeling related indicators,HYP level and incidence of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in the scores of traditional Chinese medicine syndrome,cardiopulmonary function indicators,ventricular remodeling related indicators and HYP level between the two groups(P>0.05).After treatment,the TCM syndrome score levels of edema,dyspnea and dull complexion in both groups decreased,and which in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the left ventricular ejection fraction(LVEF),peak expiratory flow rate(PEF),total lung volume(TLC)and the ratio of forced expiratory volume to forced vital capacity in one second(FEV1/FVC)increased in both groups,while the left ventricular end diastolic diameter(LVEDD)decreased,the LVEF,PEF,TLC and FEV1/FVC of the observation group were higher than those of the control group,while the LVEDD was lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the left ventricular posterior wall thickness(LVPW),inter

关 键 词：益气养心活血汤 厄贝沙坦氢氯噻嗪 慢性心力衰竭 心肺功能 羟脯氨酸 心室重构 

分 类 号：R287[医药卫生—中药学] R541.6[医药卫生—中医学]