多维度血糖波动指标对糖尿病足溃疡预后的影响  

The effect of multi-dimensional blood glucose variability index on the prognosis of diabetic foot ulcers

作　　者：吴小华[1] 陈燕[1] 邓武权 王敏[1] WU Xiaohua;CHEN Yan;DENG Wuquan;WANG Min(Department of Endocrinology and Metabolism,Chongqing University Affiliated Hospital/Chongqing Emergency Medical Center,Chongqing 400010,China)

机构地区：[1]重庆大学附属中心医院/重庆市急救医疗中心内分泌与代谢科,重庆400010

出　　处：《检验医学与临床》2024年第24期3740-3744,共5页Laboratory Medicine and Clinic

基　　金：重庆市科卫联合医学科研项目(2022QNXM018)。

摘　　要：糖尿病足溃疡(DFUs)是糖尿病最严重的临床综合征之一,常伴随着极高的截肢率和病死率。其致病因素复杂,血糖管理是DFUs临床综合治疗中的重要一环,血糖控制不良是导致DFUs发生和发展的重要危险因素之一,影响着DFUs的临床结局。糖化血红蛋白、血糖变异系数、目标范围内时间(TIR)等是目前评价血糖波动的重要指标,与糖尿病微血管及大血管并发症的发生、发展及死亡密切相关,但目前在DFUs中的研究较少,该文就糖化血红蛋白、血糖变异系数、TIR等进行综述,旨在总结现有证据,评估多维度血糖波动指标对DFUs预后的影响。Diabetic foot ulcers(DFUs)are one of the most severe complications of diabetes,with high rates of amputation and mortality.The etiology is complex,and glucose control is a critical therapy in patients with DFUs,affecting the clinical outcomes of DFUs.Poor blood glucose control is an important risk factor leading to the occurrence,development and poor prognosis of DFUs.Hemoglobin A1c,blood glucose coefficient of variation and time in range(TIR)are important indicators for evaluating blood glucose fluctuations.A large number of studies have shown that these indicators relate closely to the occurrence and development of microvascular,macrovascular complications in diabetes,but there are a few studies reported in DFUs.This article provides a review of glycated hemoglobin,blood glucose coefficient of variation and TIR.This review aimes to summarize existing evidences and evaluate the impact of multi-dimensional blood glucose fluctuation indicators on the prognosis of DFUs.

关 键 词：糖化血红蛋白 变异系数 目标范围内时间 糖尿病足溃疡 

分 类 号：R446.1[医药卫生—诊断学]