基于临床相关指标探讨2型糖尿病视网膜病变与2型糖尿病肾病的影响因素  

Influencing Factors of Type 2 Diabetic Retinopathy Combined with Type 2 Diabetic Nephropathy Based on Clinical Related Indicators

作　　者：王霄霄 时黛 顾雯 秦嘉恒 侯静 杨照康 WANG Xiaoxiao;SHI Dai;GU Wen;QIN Jiaheng;HOU Jing;YANG Zhaokang(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,Guizhou,China;The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550003,Guizhou,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025 [2]贵州中医药大学第二附属医院,贵州贵阳550003

出　　处：《糖尿病新世界》2024年第20期21-25,共5页Diabetes New World

基　　金：贵阳市科技计划项目(筑科合同[2019]-9-4-25号);2023年贵州中医药大学学术新苗项目([2023]-38号);贵州省卫生计生委科学技术基金项目(gzwjkj2014-2-120)。

摘　　要：目的探讨2型糖尿病视网膜病变(diabetic retinopathy,DR)合并2型糖尿病肾病(diabetic kidney disease,DKD)的危险因素。方法回顾性选取2021年1月—2024年1月贵州中医药大学第二附属医院收治的190例2型DR患者的临床资料,根据是否合并DKD分为单纯DR组(95例)与DR+DKD组(95例)。单因素分析单纯DR组与DR+DKD组临床资料的差异,并开展二元Logistic回归分析DR+DKD发生的影响因素。结果DR+DKD组患者尿素氮、尿微量白蛋白、24 h尿蛋白定量、糖化血红蛋白、低密度脂蛋白胆固醇均高于单纯DR组,差异均有统计学意义(P均<0.05)。二元Logistic回归分析显示,尿微量白蛋白≥30 mg/L、糖化血红蛋白≥7%是DR合并DKD的独立危险因素(P均<0.05)。结论DR、DKD的影响因素包括尿素氮、尿微量白蛋白、24 h尿蛋白定量、糖化血红蛋白、低密度脂蛋白胆固醇,其中尿微量白蛋白、糖化血红蛋白是DR合并DKD独立危险因素。Objective To investigate the risk factors of type 2 diabetic retinopathy(DR)combined with type 2 diabetic kidney disease(DKD).Methods The clinical data of 190 patients with type 2 DR admitted to the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from January 2021 to January 2024 were retrospectively selected.According to whether DKD was combined,they were divided into simple DR group(95 cases)and DR+DKD group(95 cases).The difference of clinical data between DR group and DR+DKD group was analyzed by univariate analysis,and the influencing factors of DR+DKD were analyzed by binary Logistic regression.Results The urea nitrogen,microalbuminuria,24-hour urinary protein quantification,glycated hemoglobin A1c and low-density lipoprotein cholesterol in the DR+DKD group were higher than those in the DR group,and the differences were statistically significant(all P<0.05).Binary Logistic regression analysis showed that microalbuminuria≥30 mg/L and glycated hemoglobin A1c≥7%were independent risk factors of DR combined with DKD(both P<0.05).Conclusion The influence factors of DR and DKD include urea nitrogen,microalbuminuria,24-hour urinary protein quantification,glycated hemoglobin A1c and low-density lipoprotein cholesterol.Microalbuminuria and glycated hemoglobin A1c are independent risk factors for DR combined with DKD.

关 键 词：糖尿病肾病 糖尿病视网膜病变 临床指标 影响因素 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]