高原地区糖尿病患儿维生素D水平的影响因素分析  

Analysis of Influencing Factors of Vitamin D Level in Children with Diabetes in Plateau Area

作　　者：刘志兰 孙雨葳 谢雨桐 LIU Zhilan;SUN Yuwei;XIE Yutong(Department of Endocrinology,Qinghai Women and Children's Hospital,Xining 810007,Qinghai,China;Department of Clinical Laboratory,Qinghai Women and Children's Hospital,Xining 810007,Qinghai,ChinaObjective To explore the influencing factors of vitamin D level in children with diabetes in)

机构地区：[1]青海省妇女儿童医院内分泌科,青海西宁810007 [2]青海省妇女儿童医院检验科,青海西宁810007

出　　处：《糖尿病新世界》2024年第20期26-28,34,共4页Diabetes New World

基　　金：青海省医药卫生科技项目(2020-wjzdx-99)。

摘　　要：目的探讨高原地区糖尿病患儿维生素D水平的影响因素。方法回顾性选取2017年6月—2022年6月青海省妇女儿童医院内分泌科收治的122例居住地海拔≥2100 m的糖尿病患儿的临床资料。根据不同的维生素D水平,分为维生素D不正常组(<20 ng/mL)60例和维生素D正常组(≥20 ng/mL)62例。收集两组一般资料、生理生化指标,进行单因素及多因素Logistic回归分析。结果两组性别、低密度脂蛋白、总胆固醇比较,差异均有统计学意义(P均<0.05)。多因素Logistic回归分析结果显示,低密度脂蛋白>3.4 mmol/L是高原地区糖尿病患儿发生低水平维生素D的危险因素(P<0.05)。结论在高原地区儿童糖尿病患者中,维生素D水平与性别、低密度脂蛋白和总胆固醇存在一定联系,其中低密度脂蛋白是维生素D水平的影响因素。Objective To explore the influencing factors of vitamin D level in children with diabetes in plateau area.Methods The clinical data of 122 children with diabetes living at an altitude of≥2100 m admitted to the Department of Endocrinology in Qinghai Women and Children's Hospital from June 2017 to June 2022 were retrospectively selected.According to different vitamin D levels,they were divided into vitamin D abnormal group(<20 ng/mL)of 60 cases and vitamin D normal group(≥20 ng/mL)of 62 cases.The general data,physiological and biochemical indexes of the two groups were collected for univariate and multiple Logistic regression analysis.Results There were significant differences in gender,low density lipoprotein and total cholesterol between the two groups(all P<0.05).Multiple Logistic regression analysis showed that low density lipoprotein>3.4 mmol/L was a risk factor for low level of vitamin D in children with diabetes in plateau area(P<0.05).Conclusion In children with diabetes in plateau area,vitamin D level is related to gender,low density lipoprotein and total cholesterol,and low density lipoprotein is the influencing factor of vitamin D level.

关 键 词：维生素D 高原地区 糖尿病患儿 影响因素 

分 类 号：R4[医药卫生—临床医学]