糖尿病患者采用胱抑素C、β2-微球蛋白及尿微量白蛋白检测早期肾损伤的评估分析  

Evaluation and Analysis of Early Renal Injury in Diabetic Patients with Cystatin C,β2-microglobulin and Microalbuminuria Detection

作　　者：成翠 彭军[1] 陈梦蝶 CHENG Cui;PENG Jun;CHEN Mengdie(Department of Clinical Laboratory,Funing County People's Hospital,Yancheng 224400,Jiangsu,China)

机构地区：[1]阜宁县人民医院检验科,江苏盐城224400

出　　处：《糖尿病新世界》2024年第20期35-37,41,共4页Diabetes New World

摘　　要：目的分析胱抑素C(cystatin C,CysC)、β2-微球蛋白(β2-microglobulin,β2-MG)、尿微量白蛋白(microalbuminuria,mAlb)联合检测用于糖尿病患者早期肾损伤评估的效果。方法选取2022年1月—2023年12月阜宁县人民医院收治的70例糖尿病疑似早期肾损伤患者为研究对象,全部患者均测定CysC、β2-MG、mAlb水平,以综合诊断结果为金标准,分析CysC、β2-MG、mAlb指标单一检测及联合检测的诊断效能。结果综合诊断结果显示,在70例糖尿病患者中确诊早期肾损伤阳性38例,阴性32例;β2-MG检测阳性35例、阴性35例;mAlb检测阳性36例、阴性34例;CysC检测阳性36例、阴性34例;联合诊断阳性42例、阴性28例。联合检测的灵敏度高于β2-MG、CysC、mAlb指标单一检测,差异有统计学意义(P<0.05)。不同检测方法的特异度、准确度比较,差异均无统计学意义(P均>0.05)。结论CysC、β2-MG、mAlb联合检测诊断糖尿病早期肾损伤患者的灵敏度较高,测定其水平有助于医师准确评估患者肾损伤情况,对患者疾病的治疗方案拟定、预后改善有重要意义。Objective To analyze the effect of combined detection of cystatin C(CysC),β2-microglobulin(β2-MG)and microalbuminuria(mAlb)on the evaluation of early renal injury in diabetic patients.Methods A total of 70 diabetic patients with suspected early renal injury admitted to Funing County People's Hospital from January 2022 to December 2023 were selected as the research objects.The levels of CysC,β2-MG and mAlb were measured in all patients.Taking the comprehensive diagnosis results as the gold standard,the diagnostic efficacy of single detection and combined detection of CysC,β2-MG and mAlb was analyzed.Results The results of comprehensive diagnosis showed that 38 cases of early renal injury were positive and 32 cases were negative in 70 diabetic patients.β2-MG test was positive in 35 cases and negative in 35 cases.mAlb was detected positive in 36 cases and negative in 34 cases.CysC test was positive in 36 cases and negative in 34 cases.Combined diagnosis was positive in 42 cases and negative in 28 cases.The sensitivity of combined detection was higher than that of single detection ofβ2-MG,CysC and mAlb,and the difference was statistically significant(P<0.05).There was no significant difference in the specificity and accuracy of different examination methods(both P>0.05).Conclusion The combined detection of CysC,β2-MG and mAlb has high sensitivity in the diagnosis of early renal injury in patients with diabetes.The determination of its level is helpful for doctors to accurately evaluate the renal injury of patients,and is of great significance for the formulation of treatment plan and prognosis improvement of patients.

关 键 词：Β2-微球蛋白 胱抑素C 尿微量白蛋白 糖尿病早期肾损伤 诊断价值 

分 类 号：R714.2[医药卫生—妇产科学]