加味六君子汤对脾虚湿盛型2型糖尿病患者糖脂代谢、胰岛功能的影响  

Effects of Supplemented Liujunzi Decoction on Glucose and Lipid Metabolism and Islet Function of Type 2 Diabetes Mellitus with Spleen Deficiency and Dampness Type

作　　者：刘文妃 陈礼木 林飞燕 LIU Wenfei;CHEN Limu;LIN Feiyan(Department of Integrated Chinese and Western Internal Medicine,Minqing County General Hospital Provincial Huang Branch,Fuzhou 350814,Fujian,China)

机构地区：[1]闽清县总医院省璜分院中西医结合内科,福建福州350814

出　　处：《糖尿病新世界》2024年第20期86-89,共4页Diabetes New World

摘　　要：目的探讨加味六君子汤对脾虚湿盛型2型糖尿病(type 2 diabetes mellitus,T2DM)患者糖脂代谢及胰岛功能的影响。方法选取2024年1—8月闽清县总医院省璜分院收治的64例脾虚湿盛型T2DM患者为研究对象,按照治疗方法的不同分为两组,各32例。参照组采用常规西药(二甲双胍)治疗,研究组采用中西医结合(二甲双胍+加味六君子汤)治疗。对比两组中医证候积分、糖脂代谢情况、胰岛功能及不良反应发生率。结果治疗后,研究组中医证候积分低于参照组,差异有统计学意义(P<0.05)。治疗后,研究组血糖(空腹血糖、餐后2 h血糖、糖化血红蛋白)、血脂(总胆固醇、甘油三酯、低密度脂蛋白胆固醇)指标均低于参照组,差异均有统计学意义(P均<0.05)。治疗后,研究组空腹胰岛素水平、胰岛素抵抗指数均低于参照组,胰岛β细胞功能指数高于参照组,差异均有统计学意义(P均<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论脾虚湿盛型T2DM患者治疗过程中给予加味六君子汤治疗,能够有效改善患者临床症状,降低血糖、血脂水平,促进胰岛功能的改善。Objective To investigate the effects of supplemented Liujunzi Decoction on glucose and lipid metabolism and islet function in patients with type 2 diabetes mellitus(T2DM)of spleen deficiency and dampness type.Methods From January to August 2024,64 patients with spleen deficiency and dampness type T2DM admitted to the Minqing County General Hospital Provincial Huang Branch were selected as the research objects.According to the different treatment methods,they were divided into two groups,32 cases in each group.The reference group was treated with conventional Western medicine(metformin),and the study group was treated with integrated traditional Chinese and Western medicine(metformin+supplemented Liujunzi Decoction).The traditional Chinese medicine syndrome score,glucose and lipid metabolism,islet function and incidence of adverse reactions were compared between the two groups.Results After treatment,the traditional Chinese medicine syndrome score of the study group was lower than that of the reference group,the difference was statistically significant(P<0.05).After treatment,the indexes of blood glucose(fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin A1c)and blood lipid(total cholesterol,triglyceride,low-density lipoprotein cholesterol)in the study group were lower than those in the reference group,the differences were statistically significant(all P<0.05).After treatment,the fasting insulin level and homeostasis model assessment of insulin resistance of the study group were lower than those of the reference group,and the homeostasis model assessment ofβ-cell function was higher than that of the reference group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Supplemented Liujunzi Decoction was given in the treatment of T2DM patients with spleen deficiency and dampness type,the application effect was definite,which could effectively improve the clinical sym

关 键 词：2型糖尿病 脾虚湿盛型 加味六君子汤 糖脂代谢 胰岛功能 

分 类 号：R587.1[医药卫生—内分泌]