基于脑-肠-菌轴探讨调补肝脾法治疗功能性消化不良的作用机制  

The Mechanism of Action of Tonifying Liver and Spleen Method in the Treatment of Functional Dyspepsia Based on Brain-intestine-bacteria Axis

作　　者：周擎天 邵岩峰 于莉 林平 ZHOU Qingtian;SHAO Yanfeng;YU Li;LIN Ping(Department of Spleen and Stomach,The Third People’s Hospital,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou 350003,China;Lin Ping Traditional Chinese Medicine Inheritance Studio,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou 350003,China)

机构地区：[1]福建中医药大学附属第三人民医院脾胃病科,福建福州350003 [2]福建中医药大学林平中医药传承工作室,福建福州350003

出　　处：《中国中医药现代远程教育》2025年第1期87-90,共4页Chinese Medicine Modern Distance Education of China

基　　金：福建省省级临床重点专科建设项目【No.闽卫医政函〔2023〕1163号】;福建中医药大学中医药传承工作室建设项目【No.闽中医〔2023〕56号】。

摘　　要：功能性消化不良(FD)作为临床常见疾病,其发病机制在现代医学方面被证实与胃肠动力、内脏敏感性、胃肠微生态等直接相关。脑-肠-菌轴作为一条人体的特殊通路,可较好地阐释其复杂的病理机制。中医药在FD的治疗方面有着十分确切的效果。从中医理论角度,脾胃之“运”“化”与现代医学胃肠动力、营养代谢等具有高度相似之处;而肝主疏泄影响脾胃气机,调畅情志影响思维等功能将中枢系统与胃肠道联系在一起,与现代医学“脑-肠-菌轴”高度相似。文章从中西医两方面论治FD,加强了对其病因病机与治则治法的认识,并拓展了中医调补肝脾法的思路。Functional dyspepsia,as a common clinical disease,its pathogenesis has been proved to be directly related to gastrointestinal dynamics,visceral sensitivity,gastrointestinal microecology,etc.in modern medicine.The brain-intestinal-bacterial axis,as a special pathway in the human body,can better explain its complex pathological mechanism.Traditional Chinese medicine has very precise efficacy in the treatment of functional dyspepsia.From the perspective of Chinese medicine theory,the“transportation”and“transformation”of the spleen and stomach are highly similar to the gastrointestinal dynamics and nutritional metabolism of modern medicine,and the liver’s main function is to influence the qi of the spleen and stomach and to smooth the flow of qi.The functions of the liver,which is responsible for the drainage,influencing the qi of the spleen and stomach,and the emotion influencing the thinking,etc.link the central system with the gastrointestinal tract,which is highly similar to the“brain-intestinal-bacteria axis”of modern medicine.The mutual treatment of functional dyspepsia from both traditional Chinese medicine and Western medicine can strengthen the understanding of its etiol⁃ogy,pathogenesis,and treatment principles and methods,and expand the application of Chinese medicine to tonify the liver and spleen.

关 键 词：胃脘痛 功能性消化不良 脑-肠-菌轴 作用机制 中西医结合疗法 

分 类 号：R259[医药卫生—中西医结合]