非编码RNA在皮肤光老化中的作用进展  

Role of non-coding RNAs in skin photoaging

作　　者：何泽枝 陈嘉珍 吴慧 沈郝佳 李润祥 朱慧兰 HE Zezhi;CHEN Jiazhen;WU Hui;SHEN Haojia;LI Runxiang;ZHU Huilan(Institute of Dermatology,Guangzhou Medical University;Guangzhou Dermatology Hospital,Guangzhou 510095,China)

机构地区：[1]广州医科大学皮肤病研究所 [2]广州市皮肤病医院,广东广州510095

出　　处：《皮肤性病诊疗学杂志》2024年第11期783-788,共6页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广州市科技计划项目(2024A03J0559)。

摘　　要：皮肤光老化是由于长期暴露在紫外线辐射下引起的皮肤过早老化现象,表现为皱纹、皮肤弹性丧失、色素沉着紊乱和老年斑等。非编码RNA(ncRNA)包括微小RNA、长非编码RNA和环状RNA,在调控基因表达中起着至关重要的作用,并在皮肤光老化过程中扮演了重要角色。本文综述ncRNA(如miR-34a、miR-134、miR-1246、lncRNA H19-miR-296-5p-IGF2、lncRNA PVT1-miR-551b-3p-AQP3、lncRNAMeg3-miR-93-5p-epiregulin、circ-COL3A1-859267、circ-0011129等)在皮肤光老化中的具体分子作用机制,并讨论以ncRNA为基础的治疗方法在光老化中的应用潜力。Skin photoaging,a phenomenon of premature skin aging due to prolonged exposure to ultraviolet(UV)radiation,manifests as wrinkles,loss of skin elasticity,pigmentation disorders,and age spots.Non-coding RNAs(ncRNAs),including microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs),play a crucial role in regulating gene expression and the development of skin photoaging.This review summarizes the molecular mechanisms of specific ncRNAs(such as miR-34a,miR-134,miR-1246,lncRNA H19-miR-296-5p-IGF2,lncRNA PVT1-miR-551b-3p-AQP3,lncRNAMeg3-miR-93-5p-epiregulin,circ-COL3A1-859267 and circ-0011129)in skin photoaging.Additionally,the review discusses the potential application of ncRNA-based therapies in photoaging,as well as the current challenges and future research directions.

关 键 词：皮肤光老化 NCRNA MIRNA lncRNA circRNA 炎症反应 氧化应激 细胞外基质重塑 

分 类 号：R758.1[医药卫生—皮肤病学与性病学]