可见光促进的炔酸酯合成3-磺酰香豆素衍生物  

Visible Light Promoted Synthesis of 3-Sulphonyl Coumarins from Alkyoates

作　　者：王一越 孙语谦 陈宝宽 孙京 WANG Yiyue;SUN Yuqian;CHEN Baokuan;SUN Jing(School of Petrochemical Engineering,Liaoning Petrochemical University,Fushun Liaoning 113001,China)

机构地区：[1]辽宁石油化工大学石油化工学院,辽宁抚顺113001

出　　处：《辽宁石油化工大学学报》2024年第6期10-16,共7页Journal of Liaoning Petrochemical University

基　　金：辽宁省教育厅科学技术研究项目(面上项目)(JYTMS20231453)。

摘　　要：香豆素类衍生物是一类重要的有机杂环化合物,具有良好的生物活性。通过可见光促进的苯丙炔酸酯与苯亚磺酸钠的反应制备了3-磺酰香豆素衍生物,并研究了其反应机理。结果表明,在温和的反应条件下,以苯亚磺酸钠为磺酰自由基前驱体、过硫酸盐为氧化剂,通过串联自由基加成环化策略,可以中等到良好的产率制得3-磺酰香豆素衍生物,为功能化香豆素衍生物的制备提供了一条简洁、绿色和高效的合成路线。Coumarins are a key class of heterocyclic lactone compounds,which have good biological activity.3-sulfonyl coumarin derivatives were prepared by visible light promoted reaction of benzoalkynyl esters with sodium benzenesulfonate,and their reaction mechanism was studied.The results showed that under mild reaction conditions,3-sulfonyl coumarin derivatives can be synthesized with moderate to good yields using sodium benzenesulfite as the precursor of sulfonyl radicals and persulfate as the oxidant through a cascade radical addition cyclization strategy,providing a concise,green,and efficient synthetic route for the preparation of functionalized coumarin derivatives.

关 键 词：香豆素 磺酰化 环化反应 

分 类 号：TQ254.1[化学工程—有机化工]