Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing  

作　　者：Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu Guang Yang Fulun Li 

机构地区：[1]Department of Dermatology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China [2]Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine,College of Biological Science and Medical Engineering,Donghua University,Shanghai 201620,China [3]Clinical Laboratory Medicine Center,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China

出　　处：《Nano Research》2025年第1期586-596,共11页纳米研究（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.82474515 and 82074428);Highlevel Chinese Medicine Key Discipline Construction Project(Integrative Chinese and Western Medicine Clinic)of National Administration of TCM(No.zyyzdxk-2023065);Young Qi-Huang Scholar of National Administration of Traditional Chinese Medicine,Evidence-Based Capacity Building for TCM Specialty Therapies for Skin Diseases of National Administration of TCM,and Innovative Team Projects of Shanghai Municipal Commission of Health(No.2022CX011)to Fulun Li;the National Natural Science Foundation of China(No.32371413)to Guang Yang.

摘　　要：Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical treatment.Herein,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions coordination.The unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and biocompatibility.In addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica dahurica.Our findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关 键 词：functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]