Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management  

作　　者：Shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu 

机构地区：[1]Key Laboratory of Biorheological Science and Technology,Ministry of Education,College of Bioengineering,Chongqing University,Chongqing 400044,China [2]Chongqing University Three Gorges Hospital,Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic Diseases,Chongqing 404000,China [3]Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province,Wenzhou University,Wenzhou 325035,China [4]Department of Endocrinology,School of Medicine,Chongqing Emergency Medical Center,Chongqing University Central Hospital,Chongqing 400014,China

出　　处：《Nano Research》2025年第1期618-627,共10页纳米研究（英文版）

基　　金：National Natural Science Foundation of China(Nos.32171324 and 31971301)helped to support this work,Fundamental Research Funds for Central Universities(Nos.2024CDJXY017 and 2023CDJXY-051);Fundamental Research Funds for the National Key R&D Project(No.2022YFF0710700);2030 Major Research Projects for Technological Innovation(No.2023ZD0509402);Natural Science Foundation of Chongqing(Nos.2022NSCQ-BHX4850,CSTB2022NSCQ-BHX0718,and CSTB2022NSCQ-BHX0724).

摘　　要：Diabetes,a prevalent chronic metabolic disorder,often leads to severe complications.Currently,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin injections.Hence,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin release.Functionalizing nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune escape.Simultaneously,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)scavenging.Both in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia risk.Therefore,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关 键 词：glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase HEMOGLOBIN 

分 类 号：TG14[一般工业技术—材料科学与工程]