Amino acid assisted aqueous synthesis of highly stable CsPbBr_(3)nanocrystals for cell imaging  

作　　者：Xue Li Yanan Guo Guoying Tan Qingyi Liu Nan Song Yu Tang 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry,Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China [2]State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization,Baotou Research Institute of Rare Earths,Baotou 014030,China

出　　处：《Nano Research》2025年第1期675-683,共9页纳米研究（英文版）

基　　金：support from the National Natural Science Foundation of China(Nos.22221001,and 22131007);the Science and Technology Major Plan of Gansu Province(No.23ZDGA012);the 111 project(No.B20027).

摘　　要：Lead halide perovskite nanocrystals(NCs)exhibit excellent optoelectronic performance and have drawn great interests in the fields of biological imaging and sensing.However,the poor stability of CsPbX_(3)(X=Cl,Br,I)in water is still a challenge to hinder their practical applications.In this work,a facile strategy has been developed for aqueous synthesis of CsPbX_(3) nanocrystals,in which L-glutamic acid(LGlu)has been used to replace oleic acid in the synthetic process.Benefiting from the synergic effects of L-Glu and oleylamine(OAm),CsPbBr_(3)nanocrystals(L-Glu/OAm-CsPbBr_(3)NCs)with high water stability have been directly prepared under a mild condition at room temperature in water,facilitated by the process of crystal phase transformation from Cs_(4)PbBr_(6) to CsPbBr_(3).L-Glu/OAm-CsPbBr_(3)NCs exhibit a high quantum yield of 85%and a narrow full width at half maximum of 16 nm,demonstrating their efficient luminescence in water.Typically,L-Glu on the surface have contributed greatly to an acidic environment and passivation of surface defects,improving the water stability and dispersibility of CsPbBr_(3)nanocrystals.Moreover,L-Glu/OAm-CsPbBr_(3)NCs exhibit great biocompatibility due to the presence of L-Glu,resulting in their good performance for HeLa cell imaging.Thus,we propose a facile and effective method to prepare CsPbBr_(3)nanocrystals with excellent water stability by using L-Glu and OAm as cooperated ligands and expand their application in cell imaging.

关 键 词：aqueous synthesis cell imaging lead halide perovskite nanocrystals L-glutamic acid phase transformation 

分 类 号：TB383[一般工业技术—材料科学与工程]