急性心肌梗死患者血清中BIN1水平与Killip分级之间的关系  

Association between serum BIN1 level and Killip class in patients with acute myocardial infraction

作　　者：王燕妮 黄霞 陈福恒[2] 高圆圆 崔向荣[4] 严琴 井宣 WANG Yanni;HUANG Xia;CHEN Fuheng;GAO Yuanyuan;CUI Xiangrong;YAN Qin;JING Xuan(Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030012,China;Clinical Laboratory,Shanxi Provincial People's Hospital,Fifth Hospital of Shanxi Medical University,Taiyuan 030012,China;Statistics for Laboratory Animal Centre,Shanxi Provincial People's Hospital,Taiyuan 030012,China;Reproductive Medicine Center,Women and Children's Health Center of Shanxi Province,Taiyuan 030013,China;Second Clinical College of Shanxi Medical University,Taiyuan 030002,China)

机构地区：[1]山西医科大学第五临床医学院检验科,山西太原030012 [2]山西省人民医院检验科,山西太原030012 [3]山西省人民医院实验动物中心统计学部门,山西太原030012 [4]山西省妇幼保健院生殖医学科,山西太原030013 [5]山西医科大学第二临床医学院,山西太原030002

出　　处：《南方医科大学学报》2024年第12期2388-2395,共8页Journal of Southern Medical University

基　　金：国家自然科学基金(82000302);山西省留学人员科技活动择优资助项目(20200033);山西省应用基础研究计划项目(201901D211519)。

摘　　要：目的探讨急性心肌梗死(AMI)与血清桥接整合因子(BIN1)水平之间的相关性和Killip分级之间的关系。方法实验组包括94例AMI患者,对照组包括30例未患AMI的健康体检者。检测在对照组和AMI组之间、不同Killip分类之间以及3个不同TIMI评分组之间的血清BIN1表达水平。并评估AMI患者的中性粒细胞与淋巴细胞比值(NLR)以及与BIN1的联合诊断价值。结果AMI组血清BIN1水平低于对照组(P=0.032)。KillipⅠ组的血清BIN1水平低于对照组(P=0.008)。血清BIN1水平是AMI组的独立预测因子,其预测值为0.630(95%CI:0.513-0.748),临界值为0.341 ng/mL,特异性为50%,灵敏度为78.5%;血清BIN1水平也是KillipⅠ组的独立预测因子,其预测值为0.672(95%CI:0.548-0.797),最佳临界值为0.287 ng/mL,特异性为74.1%,灵敏度为60%。NLR和血清BIN1水平联合预测AMI为0.811(95%CI:0.727-0.895),最佳临界值为0.548ng/mL,特异性为92.6%,灵敏度为62.2%。血清BIN1水平与TIMI评分组有正相关性(r=0.186,P=0.003)。结论BIN1与急性心肌梗死有关。BIN1可能有助于预测急性心肌梗死患者的短期预后,并与NLR具有联合诊断价值。Objective To investigate the correlation of serum levels of bridging integrating factor 1(BIN1)with acute myocardial infarction(AMI)and Killip class of the patients.Methods We retrospectively collected the data from 94 patients with AMI and 30 healthy individuals for analysis of the correlations of serum BIN1 levels with Killip class,TIMI scores,and neutrophil-to-lymphocyte ratio(NLR).We also assessed the diagnostic value of BIN1 combined with NLR for AMI.Results Serum BIN1 levels were significantly lower in AMI patients than in the healthy individuals(P=0.032).The AMI patients with Killip class I had significantly lower serum BIN1 levels than the healthy individuals(P=0.008).Serum BIN1 level was an independent predictor of AMI with a predictive value of 0.630(95%CI:0.513-0.748)at the optimal cutoff level of 0.341 ng/mL,a specificity of 50%,and a sensitivity of 78.5%.Serum BIN1 level was also an independent predictor for Killip class I group in the AMI patients with a predictive value of 0.672(95%CI:0.548-0.797)at the optimal cutoff level of 0.287 ng/mL,a specificity of 74.1%,and a sensitivity of 60%.For AMI diagnosis,the combination of NLR and serum BIN1 level had a predictive value of 0.811(95%CI:0.727-0.895)at the optimal cutoff level of 0.548 ng/mL,with a specificity of 92.6%and a sensitivity of 62.2%.There was a positive correlation between serum BIN1 level and TIMI score in AMI patients(r=0.186,P=0.003).Conclusion BIN1 is correlated with AMI and can be helpful for predicting short-term prognosis of the patients,and BIN1 combined with NLR has a high diagnostic value for AMI.

关 键 词：急性心肌梗死 桥接整合器1 KILLIP分级 TIMI评分 中性粒细胞与淋巴细胞比值 

分 类 号：R542.22[医药卫生—心血管疾病]