Clara细胞分泌蛋白16和骨膜蛋白与哮喘患儿维生素水平和疗效的相关性及对疗效的预测价值  

Correlation of Clara cell secretory protein 16 and periostin with vitamin levels and treatment efficacy in children with asthma and predictive value for outcome

作　　者：李小丽 杜斯斯 张松 刘彦霞 LI Xiaoli;DU Sisi;ZHANG Song;LIU Yanxia(The First Department of Pediatrics,Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang 050000,China;The Sixth Department of Infection,Shijiazhuang Fifth Hospital,Shijiazhuang 050000,China)

机构地区：[1]石家庄市妇幼保健院儿一科,石家庄050000 [2]石家庄市第五医院感染六科,石家庄050000

出　　处：《中国临床药学杂志》2024年第11期840-845,共6页Chinese Journal of Clinical Pharmacy

基　　金：2024年度河北省医学科学研究课题计划(编号20242144)。

摘　　要：目的探究Clara细胞分泌蛋白16(CC16)和骨膜蛋白与哮喘患儿维生素水平和疗效的相关性,并分析CC16和骨膜蛋白对哮喘患儿疗效的预测价值。方法选取2021年9月至2023年8月收治的120例哮喘患儿,收集治疗前、治疗1个月和3个月后患儿的CC16、骨膜蛋白、维生素A(VA)、25-羟基维生素D[25(OH)D]和维生素E(VE)水平,根据治疗3个月后的疗效将患儿分为显效组、有效组和无效组。分析骨膜蛋白和CC16水平与VA、25(OH)D、VE水平和疗效相关性。采用Logistic回归分析和受试者工作特征(ROC)曲线分析CC16和骨膜蛋白及2个指标联合预测疗效的价值。结果治疗3个月后,120例患儿中疗效为显效的有54例、有效的有45例、无效的有21例,分别作为显效组、有效组和无效组。治疗1个月和3个月后,3组CC16、25(OH)D、VA和VE水平比较差异均有统计学意义(P<0.05)。相关性分析显示,治疗前、治疗1个月和3个月后骨膜蛋白水平与VA、25(OH)D和VE水平和疗效均呈负相关(P<0.05),治疗前、治疗1个月和3个月后CC16水平与VA、25(OH)D和VE水平和疗效呈正相关(P<0.05)。Logistic回归分析和ROC曲线分析显示,CC16和骨膜蛋白预测哮喘患儿疗效的ROC曲线下面积(AUC)分别为0.734和0.733,2个指标联合预测疗效的AUC为0.910(敏感度88.89%,特异度85.71%,P<0.001)。结论哮喘患儿的CC16和骨膜蛋白水平与维生素水平和疗效相关,CC16和骨膜蛋白联合对哮喘患儿疗效的预测价值较高。AIM To study the correlation between Clara cell secretory protein 16(CC16)and periostin with vitamin levels and treatment efficacy in children with asthma,and to analyze the predictive value of CC16 and periostin for treatment efficacy.METHODS A total of 120 children with asthma in the hospital were selected from September 2021 to August 2023.Levels of serum CC16,periostin,vitamin A(VA),25 hydroxyvitamin d[25(OH)D],and vitamin E(VE)in children with different curative effects were collected before therapy,at 1 month and 3 months post-treatment.The children with asthma were categorized into groups of significant effect,effective,and ineffective based on 3 months post-treatment outcomes.The correlations between periostin and CC16 levels with vitamin A(VA),25-hydroxyvitamin D[25(OH)D],and vitamin E(VE)levels,as well as their relationship with curative effects,were analyzed.The predictive value of CC16 and periostin,individually and in combination,for treatment outcomes was assessed using Logistic regression analysis and the receiver operating characteristic(ROC)curve analysis.RESULTS After 3 months of treatment,out of 120 pediatric patients,54 showed significant effects,45 were effective,and 21 were ineffective,respectively categorized as the significant effect group,the effective group,and the ineffective group.Following 1 and 3 months of treatment,there were significant differences in the serum levels of CC16,25(OH)D,VA and VE among 3 groups(P<0.05).Correlation analysis showed that periostin was negatively correlated with serum levels of VA,25(OH)D,VE and curative effect before treatment,at 1 month and 3 months post-treatment(P<0.05).Conversely,the serum level of CC16 was positively correlated with serum levels of VA,25(OH)D,VE and curative effect before treatment,at 1 month and 3 months post-treatment(P<0.05).Logistic regression analysis and ROC curve analysis showed that the area under curve(AUC)for predicting therapeutic efficacy in asthmatic children for CC16 and periostin were 0.734 and 0.733,respectively.The

关 键 词：Clara细胞分泌蛋白16 复合维生素 骨膜蛋白 哮喘 疗效 维生素A 维生素E 25-羟基维生素D 

分 类 号：R725.6[医药卫生—儿科] R969.4[医药卫生—临床医学]