间歇性给药次数对输液用无针接头表面微生物影响的试验研究  

Experimental study on effect of intermittent administration frequency on microorganisms at the surface of needleless connectors for infusion

作　　者：林源 李黎[2] 黄萍 叶赟[3] 江淑芳[4] LIN Yuan;LI Li;HUANG Ping;YE Yun;JIANG Shu-fang(Department of Oncology,The First People’s Hospital of Changzhou,Changzhou 213000,China;Department of Tumor Radiotherapy,The First People’s Hospital of Changzhou,Changzhou 213000,China;Department of Nursing,The First People’s Hospital of Changzhou,Changzhou 213000,China;Department of Infection Management,The First People’s Hospital of Changzhou,Changzhou 213000,China)

机构地区：[1]江苏省常州市第一人民医院肿瘤科,江苏常州213000 [2]江苏省常州市第一人民医院肿瘤放射治疗科,江苏常州213000 [3]江苏省常州市第一人民医院护理部,江苏常州213000 [4]江苏省常州市第一人民医院感染管理科,江苏常州213000

出　　处：《中国感染控制杂志》2024年第12期1579-1583,共5页Chinese Journal of Infection Control

基　　金：常州市第一人民医院科技计划项目护理学科发展提升科技项目(yy2023003)。

摘　　要：目的为静脉输液过程中经无针接头(NC)间歇性给药后、再次连接输液器之前是否需要消毒提供理论依据。方法在实验室环境模拟临床静脉输液实际情况。以静脉注射为例,在不同间歇性给药次数(1~9次)时采用三磷酸腺苷(ATP)生物荧光检测技术对NC表面及输液结束后的液体进行微生物检测,每种给药次数重复试验15组,共采集270份标本并进行统计学分析,ATP检测值≤25相对光单位值(RLU)认为检测合格。结果随着间歇性给药次数增多,NC表面微生物整体逐渐增多,但均≤25 RLU;不同断开次数间NC表面微生物差异有统计学意义(P<0.001),其中,断开给药1、2、3、4次与断开9次相比,NC表面微生物差异均有统计学意义(均P<0.05),其余断开次数之间差异均无统计学意义(均P>0.05)。不同间歇性给药次数间输液结束后的液体微生物差异无统计学意义(P=0.946)。结论实验室环境中,随着间歇性给药次数增多,NC表面微生物增多,但未破坏输液过程的安全性。Objective To provide theoretical basis for determining whether disinfection is necessary before reco-nnecting the infusion device after intermittent administration of medicine via needleless connectors(NC)during intravenous infusion.Methods The actual situation of clinical intravenous infusion was simulated in a laboratory environment.Taking intravenous injection as an example,microorganisms on the surface of NC and in the remaining liquid after infusion at different intermittent administration times(1-9 times)were detected by adenosine triphosphate(ATP)bioluminescence detection technique.The experiment was repeated in 15 groups for each administration frequency,and a total of 270 specimens were detected and statistically analyzed.ATP detection value≤25 relative light unit(RLU)was considered to be qualified.Results With the increase of intermittent administration frequency,the overall microorganisms on NC surface gradually increased,but all were≤25 RLU.Microorganisms on the surface of NC among different disconnection times were statistically different(P<0.001).Compared with the microorganisms when disconnecting 9 times,numbers of microorganisms on the surface of NC with disconnection of 1,2,3,and 4 times were all statistically different,respectively(all P<0.05),while those with other disconnection frequencies did not show statistical differences among each other(all P>0.05).Microorganisms in liquid after infusion among different intermittent administration frequencies were not statistically different(P=0.946).Conclusion In laboratory environment,with the increase of intermittent administration frequency,microorganisms on the surface of NC increase,but the safety of the infusion process is not compromised.

关 键 词：无针接头 消毒时机 ATP检测 间歇性给药 

分 类 号：R181.32[医药卫生—流行病学]