儿童饮食行为与中枢性性早熟的病例对照研究  

A case-control study of dietary behavior and central precocious puberty among children

作　　者：陈雪 安文花[3] 熊兆英 樊怡薇 刘洪秀 李瑞珍 CHEN Xue;AN Wenhua;XIONG Zhaoying;FAN Yiwei;LIU Hongxiu;LI Ruizhen(School of Medicine,Wuhan University of Science and Technology,Wuhan 430081,Hubei Province,China;不详)

机构地区：[1]武汉科技大学医学部医学院,湖北430081 [2]华中科技大学同济医学院附属武汉儿童医院(武汉市保健院) [3]华中科技大学同济医学院公共卫生学院

出　　处：《中国学校卫生》2024年第11期1629-1633,共5页Chinese Journal of School Health

基　　金：国家自然科学基金项目(22236001)。

摘　　要：目的 探索武汉市儿童饮食行为、饮食频率与中枢性性早熟(CPP)之间的关系,为阐明导致儿童性早熟可能的相关饮食因素提供科学依据。方法 2023年2-12月在武汉儿童医院收集100例CPP儿童与100例健康儿童进行病例对照研究。采用问卷调查及访谈方式收集儿童及其父母社会人口学信息、儿童生活方式、近半年内儿童饮食行为及饮食频率等,采用条件Logistic回归模型分析儿童饮食行为以及饮食频率与CPP之间的关系。结果 基线调查未发现情绪性饮食、限制性饮食、外部性饮食3种饮食行为与儿童CPP存在关联(P值均>0.05)。在儿童饮食频率与CPP的关联性分析中发现,每周食用红肉>5次(OR=1.93,95%CI=1.01~3.68)、每月饮用碳酸饮料≥4次(OR=2.70,95%CI=1.03~7.08)、每月饮用果汁类含糖饮料≥4次(OR=2.31,95%CI=1.02~5.25)、进行营养品补充(OR=2.77,95%CI=1.47~5.22)的儿童罹患CPP的风险更高,而每月食用坚果≥4次(OR=0.21,95%CI=0.08~0.57)的儿童罹患CPP的风险较低(P值均<0.05)。结论 食用较多的红肉、高频次的饮用碳酸饮料和果汁类含糖饮料以及进行营养品补充可能是儿童发生CPP的促进因素,而经常食用坚果儿童发生CPP的概率较低。Objective To explore the relationship between dietary behavior,dietary frequency and central precocious puberty(CPP)among children in Wuhan,so as to provide a scientific basis for elucidating the possible and related dietary factors leading to precocious puberty.Methods From February to December 2023,100 children with CPP and 100 healthy children were collected in Wuhan Children's Hospital for a case-control study.Questionnaires and interviews were used to collect demographic information,child lifestyle,as well as dietary behavior and dietary frequency in the past six months.Conditional Logistic regression model was used to analyze the relationship of children's dietary behavior and dietary frequency with CPP.Results No associations were found between three dietary behavior,including emotional eating,restrictive eating,and external eating,with CPP at baseline(P>0.05).In the association analysis of dietary frequency and CPP,the risk of CPP was higher in those who consumed red meat>5 times/week(OR=1.93,95%CI=1.01-3.68),carbonated beverages≥4 times/month(OR=2.70,95%CI=1.03-7.08),fruit juices≥4 times/month(OR=2.31,95%CI=1.02-5.25),and nutritional supplementation(OR=2.77,95%CI=1.47-5.22),whereas the risk of CPP was lower in those who consumed nuts≥4 times/month(OR=0.21,95%CI=0.08-0.57)(P<0.05).Conclusion Consumption of higher amounts of red meat,high frequency of carbonated and juice-based sugary drinks,and nutrient supplementation may be contributing factors to the development of CPP,whereas regular consumption of nuts is less likely to be associated with the development of CPP.

关 键 词：饮食习惯 青春期 早熟 病例对照研究 回归分析 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健] R155.1[医药卫生—公共卫生与预防医学] R585