药物球囊对冠脉长病变的疗效及并发症的影响  

Effect of drug balloon therapy on the near and long term outcomes and complications of patients with diffuse long in situ coronary artery disease

作　　者：王晓飞 郭晓伟 范丽渊 Wang xiaofei;Guo xiaowei;Fan liyuan(Department of Cardiovascular Medicine,Dengfeng People's Hospital,Zhengzhou,452470,China)

机构地区：[1]河南郑州登封市人民医院,452470

出　　处：《临床心电学杂志》2024年第5期345-348,353,共5页Journal of Clinical Electrocardiology

摘　　要：目的分析冠状动脉原位弥漫性长病变患者应用药物涂层球囊(DCB)治疗的近期、远期疗效及对并发症的影响。方法选取2020年5月至2022年5月收治的68例冠状动脉原位弥漫性长病变患者,回顾性分析患者临床资料,以介入策略不同分为球囊组与支架组,分别为23例(共24处病变)、45例(共48处病变)。入组者均行PCI治疗,球囊组行药物球囊治疗,支架组行药物洗脱支架治疗,对比两组近期疗效、远期疗效及并发症情况。结果球囊组术后即刻狭窄程度高于支架组,术后即刻MLD、术后即刻管腔获得低于支架组(P<0.05);两组随访时MLD、随访时狭窄程度及净管腔获得比较,无统计学差异(P>0.05);晚期管腔丢失比较,球囊组低于支架组(P<0.05);球囊组21.74%与支架组26.67%并发症发生率比较,无统计学差异(P>0.05)。结论冠状动脉原位弥漫性长病变患者应用药物球囊治疗,相较于药物洗脱支架(DES)治疗,远期管腔丢失更少,且并发症较少,治疗安全性高。Objective To analyze the short-term and long-term effects of drug coated balloon(DCB)in the treatment of patients with in situ diffuse long coronary artery disease and its influence on complications.Methods A total of 68 patients with in situ diffuse long coronary artery lesions admitted from May 2020 to May 2022 were retrospectively analyzed and divided into balloon group and stent group according to different intervention strategies,with 23 cases(24 lesions)and 45 cases(48 lesions),respectively.All participants were treated with PCI,balloon group with drug balloon and stent group with drug-eluting stent.The short-term efficacy,long-term efficacy and complications of the two groups were compared.Results The degree of immediate postoperative stenosis in balloon group was higher than that in stent group,and immediate postoperative MLD and lumen gain were lower than that in stent group(P<0.05).There was no significant difference in MLD,stenosis degree and clean lumen between the two groups(P>0.05).Compared with late lumen loss,balloon group was lower than stent group(P<0.05).There was no significant difference in complication rate between balloon group 21.74%and stent group 26.67%(P>0.05).Conclusions Compared with drug-eluting stents(DES),the use of drug balloon therapy in patients with long diffuse coronary artery disease in situ has less long-term lumen loss and fewer complications,and the treatment is safe.

关 键 词：药物球囊治疗 近期疗效 冠状动脉原位弥漫性长病变 远期疗效 

分 类 号：R541.7[医药卫生—心血管疾病] R540.41[医药卫生—内科学]