工程化白细胞膜包被纳米载体用于炎症性相关疾病治疗的研究进展  

Research progress in engineered white blood cell membrane-coated nanocarriers for the treatment of inflammatory-related diseases

作　　者：苏琪 冯祖建 Su Qi;Feng Zujian(Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192,China)

机构地区：[1]中国医学科学院,北京协和医学院生物医学工程研究所,天津300192

出　　处：《国际生物医学工程杂志》2024年第5期472-476,共5页International Journal of Biomedical Engineering

基　　金：天津市自然科学基金青年项目(22JCQNJC00120);国家自然科学基金面上项目(82276212)。

摘　　要：白细胞作为一种免疫细胞,在对抗细菌感染、炎症性疾病和癌症方面发挥着重要作用。白细胞膜包被纳米载体(WBC-NCs)继承了源细胞膜抗原,同时表现出治疗炎症的巨大潜力。主要综述了WBC-NCs的制备及工程化白细胞膜策略,即利用物理工程、化学修饰和生物工程赋予天然细胞膜丰富的功能。还总结了工程化WBC-NCs通过药物递送、生物中和以及免疫调节等功能治疗炎症性相关疾病。总体而言,工程化WBC-NCs已经成为具有医学应用潜力的平台。White blood cell,as a type of immune cell,plays a crucial role in fighting against bacterial infections,inflammatory diseases,and cancer.White blood cell membrane-coated nanocarriers(WBC-NCs)inherit the source cell membrane antigens while exhibiting great potential for inflammation-related therapies.In this review,the preparation of WBC-NCs and the strategies of engineered white blood cell membrane were summarized,which involved utilizing physical engineering,chemical modifications,and bioengineering to endow natural cell membranes with diverse functionalities.The functions of engineered WBC-NCs were also summarized in the treatment of inflammatory-related diseases through drug delivery,biological neutralization,and immunomodulation.In general terms,engineered WBC-NCs have emerged as a platform with potential for medical applications.

关 键 词：细胞膜 白细胞 纳米载体 炎症靶向 生物中和 免疫调节 

分 类 号：R392-33[医药卫生—免疫学]