脱细胞基质材料在心肌梗死治疗中的应用进展  

Application progress of decellularized extracellular matrix in myocardial infarction treatment

作　　者：王晴宇 刘婧 王志红 张海玲[1] Wang Qingyu;Liu Jing;Wang Zhihong;Zhang Hailing(Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192,China)

机构地区：[1]中国医学科学院,北京协和医学院生物医学工程研究所,天津300192

出　　处：《国际生物医学工程杂志》2024年第5期492-496,共5页International Journal of Biomedical Engineering

基　　金：中国医学科学院医学与健康科技创新工程(2022-I2M-1-023)

摘　　要：心肌梗死是严重威胁人类健康的重大疾病之一,目前临床治疗存在难以预测的并发症,且大部分患者会因心肌丧失过多、瘢痕组织发展导致心脏功能严重下降,最终进展为心力衰竭,甚至死亡。随着生物材料快速发展,生物医用材料作为组织修复和再生研究中的重要部分,已成为心血管修复材料的研发热点。其中,脱细胞基质(dECM)材料是一类具有良好的组织相容性、低免疫原性和适宜细胞生长代谢特点的天然材料,已经应用于临床或临床前心血管组织工程或再生医学领域。主要介绍了目前组织工程中dECM材料,包括dECM制备3D打印生物墨水、静电纺丝、基质水凝胶和心肌补片,在心肌梗死治疗中的应用进展,并对其在心肌梗死治疗中的未来前景和当前面临的挑战进行总结。Myocardial infarction is one of the major diseases that seriously threaten human health.In the clinical treatment of myocardial infarction,there are unpredictable complications,and most patients will suffer a severe cardiac function decline due to excessive loss of myocardia and formation of scar tissue,eventually progressing to heart failure or even death.With rapid development of biological materials,they as an important part of tissue repair and regeneration research,have become a hot spot in the research and development of cardiovascular repair materials.Among them,decellularized extracellular matrix(dECM)materials,a class of natural materials with good histocompatibility,low immunogenicity,and suitable cell growth and metabolism characteristics,have been applied in clinical or preclinical cardiovascular tissue engineering or regenerative medicine.In this review,the application progress of dECM materials in tissue engineering,including the dECM preparation of 3D printed bioink,electrospinning,matrix hydrogel,and myocardial patch,in myocardial infarction treatment was summarized,and prospects and current challenges in the treatment of myocardial infarction were discussed.

关 键 词：脱细胞基质 组织工程 心肌梗死 心肌修复 

分 类 号：R542.22[医药卫生—心血管疾病] R318.08[医药卫生—内科学]