方酸菁染料在生物检测和治疗中的应用研究进展  

Research Progress in Squaraine Dyes for Application to Bioassay and Biotherapy

作　　者：刘勇男 宋吉亮 Liu Yongnan;Song Jiliang(School of Chemical Engineering,Ocean and Life Sciences,Dalian University of Technology,Panjin,116024)

机构地区：[1]大连理工大学化工海洋与生命学院,盘锦116024

出　　处：《化学通报》2024年第12期1381-1393,1367,共14页Chemistry

基　　金：国家自然科学基金项目(22271039);辽宁省化学助剂合成与分离省重点实验室开放课题基金项目(ZJKF2015,ZJKF2011);大连理工大学大学生创新创业训练计划项目(20231014111184)资助。

摘　　要：方酸菁染料具有特定的结构和理化性质,在可见光至近红外区具有强烈的吸收、独特的荧光性质和优异的光稳定性,被人们广泛研究用于生物成像、光敏剂和太阳能转换等多个领域。开发具有高消光系数和最大吸收波长的方酸菁染料越来越有必要。本文总结了方酸菁的结构特点、光物理性质与光稳定性,并根据方酸菁在生物医学中的研究方向重点综述了近10年来方酸菁染料在生物成像、光动力治疗、光热治疗及多模态协同治疗中的应用,为方酸菁染料的进一步开发提供参考。Squaraine dyes have specific structural and physicochemical properties,such as strong absorption in the visible to near-infrared region,unique fluorescence properties and excellent photostability.They have been widely used in many fields such as biological imaging,photosensitizer and solar energy conversion.It is increasingly necessary to develop squaraine dyes with high extinction coefficient and maximum absorption wavelength.In this paper,the structural characteristics,photophysical properties and photostability of squaraine were introduced,and the applications of squaraine dyes in bioimaging,photodynamic therapy,photothermal therapy and multimodal collaborative therapy in the past 10 years were reviewed according to the research direction of squaraine in biomedicine,so as to provide reference for further development of squaraine dyes.

关 键 词：方酸菁 生物传感 光动力治疗 光热治疗 

分 类 号：R318[医药卫生—生物医学工程] TQ610.1[医药卫生—基础医学]