Automated and integrated ultrahigh throughput screening for industrial strain enabled by acoustic-droplet-ejection mass spectrometry  

作　　者：Zhidan Zhang Chao Zhang Xu Zhang Jiuzhou Chen Ningyun Cai Shasha Zhong Zhibo Han Yan Zhu Ping Zheng Jibin Sun Changxiao Liu 

机构地区：[1]School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,117004,China [2]Key Laboratory of Engineering Biology for Low-Carbon Manufacturing,Systems Biology Centre,Technical Support Core Facilities,Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,Tianjin,300308,China [3]Institute of Traditional Chinese Medicine,University of Traditional Chinese Medicine,Tianjin,301617,China [4]College of Biotechnology,Tianjin University of Science and Technology,Tianjin,300457,China [5]State Key Laboratory of Drug Delivery and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research,Tianjin,300301,China

出　　处：《Journal of Pharmaceutical Analysis》2024年第9期1390-1392,共3页药物分析学报（英文版）

基　　金：supported by the National Key Research and Development Program of China(Grant No.:2023YFA0913900);the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project,China(Grant Nos.:TSBICIP-PTJS-003 and TSBICIP-CXRC-073).

摘　　要：Synthetic biology provides unprecedented opportunities to tackle critical issues including climate change and sustainable development by constructing microbial cell factories to produce industrially valuable biochemicals,biofuels,and biomaterials using renewable biomass resources[1],where strain screening for specific metabolic traits is a critical step.Rapid,accurate,and simultaneous quantification of multiple metabolites is critical for multi-perspective strain performance evaluation and strain screening,and a generalized method or platform will also reduce method development time to speed up the screening process.

关 键 词：STRAIN CRITICAL SCREENING 

分 类 号：R917[医药卫生—药物分析学]