昆仙胶囊联合甲氨蝶呤对类风湿关节炎患者疾病活动因子、骨代谢指标和Th17细胞的影响  

Effects of Kunxian Capsules Combined with Methotrexate on Disease Activity Factors,Bone Metabolism Indexes and Th17 Cells in Rheumatoid Arthritis Patients

作　　者：陈艳茹[1] 刘暘[1] 石鑫岳[1] 张晓炜[1] 李瑞 CHEN Yan-ru;LIU Yang;SHI Xin-yue;ZHANG Xiao-wei;LI Rui(Department of Rheumatology and Immunology,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia,010050,China)

机构地区：[1]内蒙古医科大学附属医院风湿免疫科,内蒙古呼和浩特010050

出　　处：《现代生物医学进展》2024年第21期4170-4172,共3页Progress in Modern Biomedicine

基　　金：中央引导地方科技发展资金项目(2022ZY0184)。

摘　　要：目的:观察昆仙胶囊联合甲氨蝶呤对类风湿关节炎(RA)患者疾病活动因子、骨代谢指标和辅助T(Th)17细胞的影响。方法:152例RA患者采用随机数字表法分为对照组(甲氨蝶呤治疗,76例)、研究组(昆仙胶囊联合甲氨蝶呤治疗,76例)。对比两组临床疗效、疾病活动因子[C反应蛋白(CRP)、类风湿因子(RF)、血沉(ESR)]、骨代谢指标[骨保护素(OPG)、核因子κB受体活化剂配体(RANKL)]和Th17细胞[外周血Th17细胞比例、白细胞介素(IL)-22、IL-17],同时观察两组治疗安全性。结果:与对照组治疗后相比,研究组临床总有效率更高,CRP、RF、ESR、RANKL、Th17细胞比例、IL-17、IL-22下降幅度更大,OPG升高幅度更大(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。结论:昆仙胶囊联合甲氨蝶呤治疗RA患者,可通过控制疾病活动因子、调节骨代谢指标和Th17细胞来提升治疗效果,且具有较好的安全性。Objective:To observe the effects of kunxian capsules combined with methotrexate on disease activity factors,bone metabolism indexes and helper T(Th)17 cells in rheumatoid arthritis(RA)patients.Methods:From 152 RA patients were divided into control group(methotrexate treatment,76 cases)and study group(Kunxian capsule combined with methotrexate treatment,76 cases)by random number table method.The clinical efficacy,disease activity factors[C-reactive protein(CRP),rheumatoid factor(RF),erythrocyte sedimentation rate(ESR)],bone metabolism indexes[osteoprotegerin(OPG),receptor activator of nuclear factor-κB ligand(RANKL)]and Th17 cells[peripheral blood Th17 cell ratio,interleukin(IL)-22,IL-17]were compared between two groups,and the safety in two groups was observed.Results:Compared with control group after treatment,the total effective rate in study group was higher,CRP,RF,ESR,RANKL,Th17 cell ratio,IL-17,IL-22 decreased more,OPG increased more(P<0.05).There was no difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Kunxian capsules combined with methotrexate in the treatment of RA patients,which can improve the therapeutic effect by controlling disease activity factors,regulating bone metabolism indexes and Th17 cells,and has good safety.

关 键 词：昆仙胶囊 甲氨蝶呤 类风湿关节炎 疾病活动因子 骨代谢指标 TH17细胞 

分 类 号：R593.22[医药卫生—内科学]