通络祛痛膏治疗膝骨关节炎效果研究  

Study on the effect of Tongluo Qutong plaster on knee osteoarthritis

作　　者：汪敏杰 王晓赟 熊梦婷 杭明辉 孙大卫 徐浩[1] WANG Minjie;WANG Xiaoyun;XIONG Mengting;HANG Minghui;SUN Dawei;XU Hao(Institute of Spinal Disease,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Shanghai Institute of Acupuncture and Meridian Research,Shanghai 200030,China;Department of Tuina,Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学脊柱病研究所,上海200032 [2]上海市针灸经络研究所,上海200030 [3]上海中医药大学附属龙华医院推拿科,上海200032

出　　处：《世界临床药物》2024年第11期1149-1154,共6页World Clinical Drug

基　　金：上海市卫生健康委员会卫生健康青年人才项目(2022YQ025);上海市重中之重临床医学中心(2022ZZ01009)。

摘　　要：目的评价通络祛痛膏外敷对膝骨关节炎(knee osteoarthritis,KOA)的临床疗效和安全性。方法采用分层随机化法,共纳入KOA患者480例,经区组随机化,按3∶1比例将其随机分为试验组(n=360,通络祛痛膏外敷)和对照组(n=120,奇正消痛贴膏外敷),两组疗程均为14 d。以西大略湖和麦克马斯特骨关节指数(Western Ontario and McMaster Universities arthritis index,WOMAC)总积分为主要疗效指标,以中医证候积分、膝部疼痛视觉模拟评分法(visual analogue scale,VAS)评分为次要疗效指标,评估两组疗效、皮肤刺激症状及不良反应情况。结果治疗后,两组WOMAC总积分、中医证候积分及膝部疼痛VAS评分较前差异显著(P<0.05),组间无显著差异(P>0.05)。两组不良反应发生情况无显著差异(P>0.05)。结论通络祛痛膏外敷治疗KOA安全、有效,可显著减轻膝部疼痛,改善患者关节活动能力及生活质量,具有临床推广价值。Objective To evaluate the clinical efficacy and safety of Tongluo Qutong plaster in the treatment of knee osteoarthritis(KOA).Methods A total of 480 patients with KOA were included by stratified randomization,and they were randomly divided into experimental group(n=360,external application of Tongluo Qutong plaster)and control group(n=120,external application of Qizheng Xiaotong plaster)according to the ratio of 3∶1.The treatment course of both groups was 14 days.The total score of Western Ontario and McMaster Universities arthritis index(WOMAC)was used as the main therapeutic index,and the TCM syndrome score,visual analogue scale(VAS)score were used as secondary efficacy indexes to evaluate the efficacy,skin irritation symptoms and adverse reactions of the two groups.Results After treatment,the total WOMAC score,TCM syndrome score and VAS score of knee pain in the two groups were significantly different from those before treatment(P<0.05),but there was no significant difference between the two groups(P>0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Tongluo Qutong plaster is safe and effective in the treatment of KOA,which can significantly reduce knee pain,improve joint mobility and quality of life of patients,and has clinical value.

关 键 词：通络祛痛膏 膝骨关节炎 随机对照研究 外用药 

分 类 号：R274.9[医药卫生—中西医结合] R684.3[医药卫生—中医骨伤科学]