臭氧对气道炎症性疾病影响的研究进展  

Research progress about effects and mechanisms of ozone on airway inflammation diseases

作　　者：蒋宛平 谷伟[1] JIANG Wanping;GU Wei(Department of Respiratory,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,Jiangsu Province,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)呼吸科,江苏南京210006

出　　处：《世界临床药物》2024年第11期1192-1198,共7页World Clinical Drug

摘　　要：地表臭氧污染对人类呼吸系统的健康产生严重威胁,吸入臭氧在气道炎症性疾病发生、发展中的作用及其机制是当前研究热点。吸入的臭氧主要与气道表面的衬液成分发生反应而降解,同时产生活性氧、脂质过氧化物及其他产物,从而刺激肺泡巨噬细胞及气道上皮细胞等,激活与炎症相关的细胞信号通路及促炎症消退脂质介质改变,进而促进气道炎症的发生、发展。该文就臭氧吸入后呼吸道损伤过程中的炎症表型及炎症产生的相关机制作一综述。Ground-level ozone pollution poses an existential threat to the health of the human respiratory system,and the role and mechanism of ozone inhalation in the occurrence and development of airway inflammatory diseases are research hotspots.Inhaled ozone mainly reacts with the components of the airway surface liquid and then degrades,while producing reactive oxygen species,lipid oxidation products and other products,thereby stimulating alveolar macrophages and airway epithelial cells,activating cell signaling pathways related to inflammation and changing in pro-inflammatory lipid mediators.All these changes promote the occurrence and development of airway inflammation.This article reviewed the inflammatory phenotypes and related mechanisms of inflammation during the process of ozone-inhalation injury.

关 键 词：臭氧 气道炎症 氧化应激 脂质过氧化物 支气管哮喘 慢性阻塞性肺炎 

分 类 号：R562[医药卫生—呼吸系统] R563.9[医药卫生—内科学]