小剂量艾司氯胺酮在老年髋关节置换术后镇痛的研究  

Study on Low-Dose Esketamine for Postoperative Analgesia of Elderly Patients with Hip Replacement Surgery

作　　者：马苒允 丁宝纯[2] 高金霞[3] MA Ranyun;DING Baochun;GAO Jinxia(Dalian Medical University,Dalian,Liaoning 116000;Huludao City Central Hospital,Huludao,Liaoning 125000;Dalian Medical University Affiliated Second Hospital,Dalian,Liaoning 116000)

机构地区：[1]大连医科大学,辽宁大连116000 [2]葫芦岛市中心医院,辽宁葫芦岛125000 [3]大连医科大学附属第二医院,辽宁大连116000

出　　处：《智慧健康》2024年第27期112-114,共3页Smart Healthcare

摘　　要：目的评估在老年全髋关节置换术后用于镇痛的舒芬太尼、右美托咪定与小剂量艾司氯胺酮联合应用的安全性及有效性。方法选取2023年6—8月在葫芦岛市中心医院接受腰-硬联合麻醉下老年全髋关节置换术的40例患者为研究对象,并根据术后镇痛方式将患者随机分为对照组和实验组,每组20例。其中,对照组采用舒芬太尼联合右美托咪定,实验组采用小剂量艾司氯胺酮联合舒芬太尼右美托咪定。比较两组患者的术后镇痛效果及血流动力学参数情况。结果实验组患者4h、8h、24h、48h镇痛效果明显优于对照组(P<0.05);实验组患者的4h、8h、24h、48h血流动力学更加稳定(P<0.05)。结论在舒芬太尼联合右美托咪定的基础上加入小剂量艾司氯胺酮可维持血流动力学的稳定,提供更好的镇痛效果。Objective The study in to evaluate the safety and effect of sufentanil,dexmedetomidine combined with low-dose esketamine for pain relief of elderly patients after total hip replacement surgery.Methods The research subjects are 40 elderly patients who underwent total hip replacement surgery under lumbar hard anesthesia at Huludao Central Hospital from June 2023 to August 2023.According to the postoperative analgesia method,patients were randomly divided into two groups:the control group(sufentanil combined with dexmedetomidine group,20 cases)and the experimental group(lowdose esketamine combined with sufentanil and dexmedetomidine group,20 cases).The postoperative analgesic effect and hemodynamic parameters were compared between two groups.Results The analgesic effect of the experimental group patients at 4h,8h,24h,and 48h was significantly better than the control group,(P<0.05).And the hemodynamics of the experimental group patients was more stable at 4h,8h,24h,and 48h,(P<0.05).Conclusion Low-dose esketamine based on sufentanil combined with dexmedetomidine can maintain hemodynamic stability and provide better analgesic effect.

关 键 词：艾司氯胺酮 舒芬太尼 右美托咪定 全髋关节置换术 术后镇痛 

分 类 号：R614[医药卫生—麻醉学]