二甲双胍联合激素治疗肥胖型多囊卵巢综合征的效果及对BMI和性激素水平的影响  

Effect of Metformin Combined with Hormone Therapy on Obese Polycystic Ovary Syndrome and BMI and Sex Hormone Levels

作　　者：刘凤莲 陈凤随 文静 LIU Fenglian;CHEN Fengsui;WEN Jing(Obstetrics and Gynecology Department,Dongguan City Integrated Traditional Chinese and Western Medicine Hospital,Dongguan,Guangdong 523820)

机构地区：[1]东莞市中西医结合医院妇产科,广东东莞523820

出　　处：《智慧健康》2024年第29期19-21,共3页Smart Healthcare

摘　　要：目的观察二甲双胍联合激素治疗肥胖型多囊卵巢综合征(PCOS)的效果及对BMI和性激素水平的影响。方法选取2020年1月—2023年1月在东莞市中西医结合医院妇产科接受治疗的80例肥胖型PCOS患者,按照1∶1的比例分为单一用药组和联合用药组。单一用药组患者接受优思明治疗,联合用药组患者则联合口服二甲双胍缓释片,均持续治疗6个月经周期。记录两组患者的治疗有效率,并通过化学发光法测定血清性激素水平,计算促黄体生成素(LH)与血清促卵泡生成素(FSH)的比值;同时进行阴道超声检查以评估卵巢功能。结果治疗后,联合用药组BMI值、血清LH、睾酮(T)、泌乳素(PRL)水平和LH/FSH值明显较低,疗效明显较高(P<0.05);两组血清FSH水平对比,差异无统计学意义(P>0.05);联合用药组患者卵泡数量明显较少,两侧卵巢体积明显较小,最大卵泡直径明显较大(P<0.05)。结论联合治疗肥胖型PCOS的临床疗效好,可改善患者BMI和激素水平,恢复卵巢功能,值得临床推广应用。Objective To observe the effect of metformin combined with hormone therapy on obese PCOS and BMI and sex hormone levels.Methods The paper chose 80 obese PCOS patients in the obstetrics and gynecology department of Dongguan City Integrated Traditional Chinese and Western Medicine Hospital from January 2020 to January 2023,and divided them into the single medication group and the combination medication group in a 1:1 ratio.The monotherapy group was treated with yasmin,while the combination therapy group with oral metformin sustained-release tablets for 6 menstrual cycles.Effective rate of treatment of two groups was recorded,serum sex hormone level was detected with chemiluminescence method,ratio of luteinizing hormone(LH)/serum follicle stimulating hormone(FSH)was calculated,and ovarian function was detected with vaginal ultrasound examination.Results After treatment,the BMI value,serum LH,testosterone(T),prolactin(PRL)levels,and LH/FSH value were significantly lower in the combination therapy group,curative effect was significantly higher,(P<0.05).There was no significant difference in serum FSH levels between two groups(P>0.05).The number of follicles in the combination therapy group was significantly fewer,volume of ovaries on both sides was significantly smaller,maximum follicle diameter was significantly larger(P<0.05).Conclusion Combination therapy can achieve good clinical effect for for obese PCOS,can improve BMI and hormone levels,restore ovarian function of patients,which is worthy of clinical promotion and application.

关 键 词：二甲双胍 多囊卵巢综合征 性激素水平 卵巢功能 体质量指数 

分 类 号：R711.75[医药卫生—妇产科学]