肺功能检查各指标截断值在COPD诊断及疗效评估中的临床价值研究  

Clinical Value Research of Cutoff Values of Various Indicators in Pulmonary Function Examination for Diagnosis and Effect Evaluation of COPD

作　　者：陈祖彭 全海金 CHEN Zupeng;QUAN Haijin(Deqing County People's Hospital,Zhaoqing,Guangdong 526600)

机构地区：[1]德庆县人民医院,广东肇庆526600

出　　处：《智慧健康》2024年第29期86-88,92,共4页Smart Healthcare

摘　　要：目的探讨肺功能指标的截断值对慢性阻塞性肺疾病(COPD)诊断及疗效评估的价值。方法选取2022年1月—2023年3月本院收治的81例COPD患者作为实验组,选取同期进行健康体检的80例健康个体作为对照组。两组均采用肺功能检测仪进行测量,测定第一秒用力呼气容积(FEV1)、用力肺活量(FVC)水平,并计算FEV1/FVC比值。根据实验组的病情分期,分成急性加重期(25例)与缓解期(56例),对比各组及实验组不同分期的肺功能检测结果,对实验组治疗前后不同时间检测结果进行对比,绘制受试者工作曲线(ROC)评价肺功能指标对COPD诊断及疗效评估的价值,并且获得截断值及灵敏度指标。结果实验组FEV1、FVC、FEV1/FVC水平低于对照组(P<0.05);急性加重期COPD者FEV1、FVC水平低于缓解期COPD者(P<0.05),急性加重期与缓解期的FEV1/FVC结果差异无统计学意义(P>0.05)。实验组患者治疗2周、1个月的FEV1、FVC、FEV1/FVC均较治疗前升高(P<0.05)。ROC曲线下FEV1(截断值为1.25L,灵敏度为88.25%)、FVC(截断值为1.77L,灵敏度为90.12%)、FEV1/FVC(截断值为60.15%,灵敏度为93.25%)的诊断效能均较高。结论肺功能的指标截断值可作为COPD诊断及疗效评估的参考,诊断价值高。Objective To explore the value of cutoff values of pulmonary function indicators in diagnosis and effect evaluation of chronic obstructive pulmonary disease(COPD).Methods The paper chose 81 COPD patients from January 2022 to March 2023 as the experimental group,and 80 patients with health examination during the same period as the control group.The first second forced expiratory volume(FEV1)and forced vital capacity(FVC)levels were detected in two groups with pulmonary function testing device,and the FEV1/FVC ratio was calculated.According to disease staging of the experimental group,patients were divided into acute exacerbation stage 25 cases and remission stage56 cases.Pulmonary function test results of each group and those in the experimental group at different stages were compared.Based on comparison of test results before and after treatment in the experimental group at different time,receiver operating characteristic(ROC)curve was drawn to evaluate value of pulmonary function indicators in diagnosis and effect evaluation of COPD,and obtaine cutoff values and sensitivity indicators.Results The levels of FEV1,FVC,and FEV1/FVC in the experimental group were lower than the control group(P<0.05).The levels of FEV1 and FVC of COPD patients with acute exacerbation were lower than those with remission(P<0.05),there was no statistically significant difference in FEV1/FVC results between acute exacerbation and remission(P>0.05).The FEV1,FVC,and FEV1/FVC in the experimental group were higher 2 weeks and 1 month after treatment than before(P<0.05).Under the ROC curve,indicators of FEV1(cut-off value of 1.25L,sensitivity of 88.25%),FVC(cut-off value of 1.77L,sensitivity of 90.12%),and FEV1/FVC(cut-off value of 60.15%,sensitivity of 93.25%)showed high diagnostic effect.Conclusion Cutoff value of pulmonary function indicators can be reference for diagnosis and effect evaluation of COPD,with good diagnostic value.

关 键 词：慢性阻塞性肺疾病 肺功能检查 截断值 诊断 疗效评估 

分 类 号：R563.9[医药卫生—呼吸系统]