表面增强拉曼光谱技术在口腔疾病中的研究进展  

Research progress of surface-enhanced Raman spectroscopy technology in oral diseases

作　　者：苟丽晨 任彪[1] GOU Li-chen;REN Biao(State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院口腔疾病防治全国重点实验室,四川成都610041

出　　处：《化学研究与应用》2024年第12期2737-2746,共10页Chemical Research and Application

基　　金：国家自然科学基金项目(81991500,81991501)资助。

摘　　要：表面增强拉曼光谱(SERS)技术能提供分子的指纹信息,具有灵敏度高、不受水峰干扰、无损分析、无需复杂前处理步骤等优势,适用于分析生物样本。SERS技术可以快速分析疾病标志物的含量或结构,有利于口腔疾病的早期诊断。本文简要介绍了SERS的发展、增强机理和改善SERS性能的方法,综述了SERS技术在龋病、牙周病、口腔癌等口腔疾病方面的应用,并展望了其发展趋势。Surface-enhanced Raman spectroscopy(SERS)technology can provide fingerprint information of molecules,has the advanta-ges of high sensitivity,no interference from water peaks,nondestructive analysis,and no need for complex pre-treatment processes,and is suitable for the analysis of biological samples.It can be quickly analyzed the content or structure of disease markers by SERS tech-nology,which can be beneficial for early diagnosis of oral diseases.In this paper,the development,enhancement mechanism,and meth-ods to improve the performance of SERS have been briefly introduced.It has been also reviewed of the application of SERS technology in oral diseases such as dental caries,periodontal disease,and oral cancer,and as well as the outlook of the development trends.

关 键 词：表面增强拉曼光谱(SERS) 口腔疾病 分子水平 

分 类 号：O657.3[理学—分析化学]