Bead-based microfluidic platforms for multiplex and ultrasensitive immunoassays in clinical diagnosis and treatment  

作　　者：Xiaoxia Fang Yiwen Yang Heni Wang Hong Xu 

机构地区：[1]School of Biomedical Engineering/Med-X Research Institute,Shanghai Jiao Tong University,Shanghai,China

出　　处：《Mechanobiology in Medicine》2024年第2期21-34,共14页力学生物学与医学（英文）

基　　金：supported by the National Natural Science Foundation of China[grant numbers 32001067,82272122,and 31927803];Inter-disciplinary Program of Shanghai Jiao Tong University[grant number YG2022ZD028];Major Projects of Special Development Funds for Shanghai Zhangjiang National Innovation Demonstration Zone[grant number ZJ2021-ZD-007].

摘　　要：Multiplex ultrasensitive detection of low abundance proteins remains a significant challenge in clinical applications,necessitating the development of innovative solutions.The integration of bead-based microfluidic chip platforms with their efficient target capture and separation capabilities,along with the advantages of miniaturization and low reagent consumption,holds great promise for building an integrated point-of-care testing(POCT)system that enables seamless sample input-result output.This review presents a comprehensive overview of recent advancements in bead-based microfluidic platforms for multiplex and ultrasensitive immunoassays,along with their potential applications in clinical diagnosis and treatment,which is organized into four sections:encoding techniques,the role of microfluidic platforms,applications,and future prospects.

关 键 词：Microfluidic Beads-based immunoassays Multiplex Ultrasensitive Clinical application 

分 类 号：R44[医药卫生—诊断学]