Microfluidic investigation for shear-stress-mediated repair of dysglycemia-induced endothelial cell damage  

作　　者：Si-Yu Hu Chun-Dong Xue Yong-Jiang Li Shen Li Zheng-Nan Gao Kai-Rong Qin 

机构地区：[1]School of Mechanical Engineering,Dalian University of Technology,No.2,Linggong Rd.,Dalian 116024,Liaoning Province,China [2]School of Biomedical Engineering,Faculty of Medicine,Dalian University of Technology,No.2,Linggong Rd.,Dalian 116024,Liaoning Province,China [3]Central Hospital of Dalian University of Technology,No.826,Xinan Rd.,Dalian 116033,Liaoning Province,China

出　　处：《Mechanobiology in Medicine》2024年第3期40-50,共11页力学生物学与医学（英文）

基　　金：supported by the National Natural Science Foundation of China(grant numbers 12372304,12172081)。

摘　　要：Dysglycemia causes arterial endothelial damage,which is an early critical event in vascular complications for diabetes patients.Physiologically,moderate shear stress(SS)helps maintain endothelial cell health and normal function.Reactive oxygen species(ROS)and calcium ions(Ca^(2+))signals are involved in dysglycemia-induced endothelial dysfunction and are also implicated in SS-mediated regulation of endothelial cell function.Therefore,it is urgent to establish in vitro models for studying endothelial biomechanics and mechanobiology,aiming to seek interventions that utilize appropriate SS to delay or reverse endothelial dysfunction.Microfluidic technology,as a novel approach,makes it possible to replicate blood glucose environment and accurate pulsatile SS in vitro.Here,we reviewed the progress of microfluidic systems used for SS-mediated repair of dysglycemia-induced endothelial cell damage(ECD),revealing the crucial roles of ROS and Ca^(2+)during the processes.It holds significant implications for finding appropriate mechanical intervention methods,such as exercise training,to prevent and treat cardiovascular complications in diabetes.

关 键 词：MICROFLUIDICS DYSGLYCEMIA Endothelial cells Shear stress ROS and Ca^(2+)signaling 

分 类 号：R318[医药卫生—生物医学工程]