NF-κB信号通路与病毒性心肌炎  

Nuclear factorκB signaling pathway in viral myocarditis

作　　者：邱月清 陈振翼[1,2] 申晓秋 宋成昊 孔桂选 王振涛 QIU Yueqing;CHEN Zhenyi;SHEN Xiaoqiu;SONG Chenghao;KONG Guixuan;WANG Zhentao(Henan University of Chinese Medicine,Zhengzhou 450053,China;Henan Provincial Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450053,China)

机构地区：[1]河南中医药大学,郑州450053 [2]河南省中医院/河南中医药大学第二附属医院,郑州450053

出　　处：《中国实验动物学报》2024年第11期1445-1455,共11页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金面上项目(81573920);2023年度河南省重点研发与推广专项(科技攻关)(232102310432);河南省中医学“双一流”创建科学研究专项(HSRP-DFCTCM-2023-1-20)。

摘　　要：病毒性心肌炎(viral myocarditis,VMC)是心肌炎中最常见的类型,可迁延至慢性心肌炎症甚至心力衰竭,最终导致死亡。核转录因子κB(nuclear factorκB,NF-κB)是一种多功能转录因子,参与调节广泛的生物过程。现有证据表明,促炎和抗炎之间的平衡对VMC的预后起决定性作用,NF-κB通路不仅可介导炎症反应,还可调控细胞焦亡、能量代谢、氧化应激、胰岛素抵抗等途径参与VMC的病理进展。本文从以上5个方面分析与总结NF-κB信号通路调控VMC的分子机制,以期为VMC未来的基础研究及临床诊治提供参考。Viral myocarditis(VMC),as the most common type of myocarditis,can progress to chronic myocarditis and even heart failure,ultimately leading to death.Nuclear factorκB(NF-κB)is a multifunctional transcription factor involved in regulating a wide range of biological processes.Existing evidence suggests that the balance between proinflammatory and anti-inflammatory factors plays a decisive role in the prognosis of VMC.The NF-κB pathway mediates inflammatory responses and regulates pathways such as cell apoptosis,energy metabolism,oxidative stress,and insulin resistance to participate in the pathological progression of VMC.This article analyzes and summarizes the molecular mechanism of NF-κB signaling pathway regulation in VMC from the above five aspects,to provide a reference for future basic research and for the clinical diagnosis and treatment of VMC.

关 键 词：核转录因子ΚB 病毒性心肌炎 炎症反应 细胞焦亡 能量代谢 胰岛素抵抗 氧化应激 

分 类 号：Q95-33[生物学—动物学]