180例咳嗽变异性哮喘患者中医证候分布特点分析  

Analysis of traditional Chinese medicine syndrome distribution characteristics in 180 patients with cough variant asthma

作　　者：闵璐 冯淬灵[2] MIN Lu;FENG Cuiling(Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院呼吸科,100700 [2]北京大学人民医院中医科

出　　处：《环球中医药》2024年第12期2495-2502,共8页Global Traditional Chinese Medicine

基　　金：北京市重大疫情防治重点专科项目(京卫医[2022]107号)。

摘　　要：目的分析咳嗽变异性哮喘(cough variant asthma,CVA)患者的中医证候分布特点。方法采用横断面研究方法,以180例CVA患者为研究对象,通过问卷调查收集患者一般资料(性别、年龄、既往史等)信息、中医四诊信息、咳嗽症状积分(cough symptom score,CSS)、视觉模拟量表(visual analog scale,VAS)、莱切斯特咳嗽问卷(Leicester cough questionnaire,LCQ)评分、焦虑自评量表(self-rating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)评分。应用SPSS 24.0软件进行统计分析,统计CVA患者中医证候分布情况,分析中医证候与患者性别、年龄、过敏性疾病史、病程、咳嗽症状积分、LCQ、VAS之间的相关性,评估CVA患者焦虑抑郁(SAS、SDS)情况。结果CVA患者单一证候中以风邪犯肺证最常见,兼夹证候多为虚实夹杂,以风邪犯肺证+脾气虚证最常见。新冠感染诱发的CVA患者与非新冠感染诱发的CVA患者均以风邪犯肺证为最常见证候类型。中医证候与患者性别、年龄、过敏性疾病史、咳嗽症状积分、咳嗽VAS评分、LCQ评分之间无显著相关性,病程>6个月时易出现肺气虚证。新冠疫情防控放开后纳入的120例患者以新冠感染为最主要的发病诱因。CVA患者SAS评分显著高于国内正常人群均值(P<0.01)。结论CVA患者中医证候以风邪犯肺证为主,可兼见脾气虚、肺气虚等证候,病机特点多以实证为主,部分患者可见本虚标实。CVA迁延不愈,病程延长,容易出现肺气虚损证候。新冠感染容易诱发气道高反应;CVA容易引发患者的焦虑情绪。Objective To analyze the distribution characteristics of traditional Chinese medicine syndromes in patients with cough variant asthma(CVA).Methods Using a cross-sectional study method,180 patients with CVA were selected as the research subjects.General information(gender,age,medical history,etc.),traditional Chinese medicine diagnosis information,cough symptom score(CSS),visual analog scale(VAS)score,Leicester cough questionnaire(LCQ)score,self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score were collected through a questionnaire survey.Statistical analysis was conducted using SPSS 24.0 software to analyze the distribution of traditional Chinese medicine(TCM)syndromes in CVA patients.The correlation between TCM syndromes and patient gender,age,history of allergic diseases,course of disease,CSS,VAS,and LCQ were analyzed.Evaluate the anxiety and depression status(SAS、SDS)of CVA patients.Results Among the single syndromes of CVA patients,the wind evil invading the lungs syndrome is the most common,while the mixed syndrome is mostly a mixture of deficiency and excess,with the wind evil invading the lungs syndrome and spleen qi deficiency syndrome being the most common.The most common syndrome type of CVA patients induced by COVID-19 infection and those induced by non COVID-19 infection is the syndrome of wind evil invading the lung.There is no significant correlation between traditional Chinese medicine syndrome and patient gender,age,history of allergic diseases,cough symptom score,cough VAS score,LCQ score.Lung qi deficiency syndrome is easy to appear when the course of disease is over 6 months.After the control of COVID-19 was released,COVID-19 infection was the main inducement of 120 patients.The SAS score of CVA patients is significantly higher than the average of the normal population in China(P<0.01).Conclusion The traditional Chinese medicine syndrome of cough variant asthma patients is mainly characterized by wind evil invading the lungs,which can also be accompanied by spleen qi defi

关 键 词：咳嗽变异性哮喘 中医证候 横断面研究 分布规律 证素 

分 类 号：R259[医药卫生—中西医结合]