针灸治疗轻中度产后抑郁症作用机制研究进展  

Mechanism of acupuncture in the treatment of mild and moderate postpartum depression:A review

作　　者：胡茜媛 杨福霞[2] 李梦雨 张溢文 顾传深 吴成亮 袁艳 罗文舒[2] 吕晓颖[5] HU Xiyuan;YANG Fuxia;LI Mengyu;ZHANG Yiwen;GU Chuanshen;WU Chengliang;YUAN Yan;LUO Wenshu;LYU Xiaoying(The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen 518033,China)

机构地区：[1]广州中医药大学第四临床医学院,深圳518033 [2]深圳市中医院针灸科 [3]深圳市中医院信息中心 [4]深圳市中医院超声影像科 [5]中国中医科学院中医临床基础医学研究所

出　　处：《环球中医药》2024年第12期2596-2601,共6页Global Traditional Chinese Medicine

基　　金：国家重点研发计划(2017YFC1703600);广东省医学科学技术研究基金(A2022116);深圳市“医疗卫生三名工程”(SZZYSM202311002)。

摘　　要：产后抑郁症是发生于产妇分娩后这一特殊阶段的抑郁症,不仅影响产妇的身心健康,还会干扰母婴关系的建立,对婴儿的成长产生长远的负面影响。现有研究表明,针灸能够提高产后抑郁症患者血清内雌二醇和孕激素浓度,下调促肾上腺皮质激素和皮质醇含量,并调节5-羟色胺、多巴胺、去甲肾上腺素、γ-氨基丁酸等神经递质水平。此外,针灸还具有调整脑肠轴功能和脑部结构功能的作用,通过增加患者肠道内有益菌如双歧杆菌和乳酸杆菌的数量,或改善脑区功能连接及其异常状态从而缓解抑郁症状。本文从针灸调节内分泌激素水平、改善神经递质水平、优化脑肠轴功能、改善脑部结构及功能4方面,探讨针灸治疗产后抑郁症的机制,以期为研究人员对针灸治疗该病的更深入探索和临床诊疗提供新的思路。Postpartum depression is a form of depression that occurs during the unique period following childbirth.It not only affects the mother’s physical and mental health but also interferes with the establishment of the mother-infant bond and has long-term negative effects on the baby’s development.Existing research indicates that acupuncture can increase serum estradiol and progesterone concentrations in patients with postpartum depression,down-regulate the levels of adrenocorticotropic hormone and cortisol,and regulate the levels of neurotransmitter,including 5-hydroxytryptamine,dopamine,norepinephrine,and γ-aminobutyric acid.Additionally,acupuncture can adjust the function of the brain-gut axis and improve brain structure and function.It can alleviate depressive symptoms by increasing the number of beneficial bacteria in the patient’s tissues of intestines,such as bifidobacteria and lactobacilli,or by improving the functional connections and abnormal conditions in brain areas.This article reviewed the mechanisms of acupuncture in treating postpartum depression from four perspectives:regulating endocrine hormone levels,improving neurotransmitter levels,optimizing brain-gut axis function,and enhancing brain structure and function.The destin was to provide deeper insights into the use of acupuncture for this condition and to offer new ideas for clinical diagnosis and treatment.

关 键 词：针灸 产后抑郁症 作用机制 内分泌激素 神经递质 脑肠轴 功能性磁共振成像 研究进展 

分 类 号：R245[医药卫生—针灸推拿学]