^(18)F-NaF与 ^(99)Tc^(m)-MDP全身骨显像图像质量与辐射剂量率的对比研究  

A Comparative Study of Image Quality and Residual Dose Between ^(18)F-NaF and ^(99)Tc^(m)-MDP Whole Body Bone Imaging

作　　者：莫碧云 牟兴宇 黎祖国 曾钰瀧 崇维霞 付巍[1] MO Biyun;MOU Xingyu;LI Zuguo;ZENG Yulong;CHONG Weixia;FU Wei(Department of Nuclear Medicine,Affiliated Hospital of Guilin Medical College,Guilin 541000,China)

机构地区：[1]桂林医学院附属医院核医学科,广西桂林541000

出　　处：《标记免疫分析与临床》2024年第11期1966-1970,2029,共6页Labeled Immunoassays and Clinical Medicine

基　　金：广西医疗卫生适宜技术开发与推广应用项目(编号:S2020111)。

摘　　要：目的对比研究^(18)F-NaF PET全身骨显像与^(99)Tc^(m)-MDP SPECT全身骨显像图像质量和辐射剂量率。方法收集2021年10月至2022年1月在桂林医学院附属核医学科行全身骨显像的患者97例,分别行^(99)Tc^(m)-MDP和^(18)F-NaF显像。收集患者相关临床资料、注射后检查等待时间、检查结束后及24h的1m距离的平均辐射剂量率及诊断医师对两种显像的图像质量,并对两种显像剂患者组间差异进行比较。结果^(18)F-NaF全身骨显像注射后检查等待时间明显少于^(99)Tc^(m)-MDP全身骨显像,且差异具有统计学意义(P<0.001);18 F-NaF全身骨显像图像质量高于^(99)Tc^(m)-MDP全身骨显像,图像质量评分(2.8±0.4 vs 2.1±0.7,t=-6.767,P<0.001),且差异有统计学意义。检查后^(18)F-NaF全身骨显像对周围环境的辐射剂量率高于^(99)Tc^(m)-MDP全身骨显像,且差异具有统计学意义(17.2±6.3μSv/h vs 5.7±4.9μSv/h,t=-9.278,P<0.001)。而24h后两显像方式的辐射剂量率相似,且差异不具有统计学意义(0.5±0.3μSv/h vs 0.6±0.3μSv/h,t=1.653,P=0.102)。结论18 F-NaF全身骨显像较^(99)Tc^(m)-MDP全身骨显像缩短了检查等待时间,并具有更高的图像质量和评分一致性。另外,两种显像剂检查后24h辐射剂量率相似。Objective To compare the image quality and radiation dose rate of ^(18)F-NaF PET whole body bone imaging and ^(99)Tc^(m)-MDP SPECT whole body bone imaging.i Methods From October,2021 to January,2022,97 patients who underwent whole-body bone imaging in the Nuclear Medicine Department of Guilin Hospital were collected for the study.^(99)Tc^(m)-MDP and ^(18)F-NaF imaging were performed respectively.Clinical data of all patients,as well as post-injection examination waiting time,average radiation dose rate at 1m distance after examination and 24h,and image quality between the two imaging agents were collected,and the differences between the two imaging agents were evaluated.Results The waiting time of 18 F-NaF whole-body bone imaging after injection was significantly shorter than that of ^(99)Tc^(m)-MDP whole-body bone imaging(P<0.001).The image quality of 18 F-NaF whole-body bone imaging was significantly higher than that of ^(99)Tc^(m)-MDP whole-body bone imaging(2.8±0.4 vs 2.1±0.7,t=-6.767,P<0.001).After examination,the radiation dose rate of 18 F-NaF whole-body bone imaging was significantly higher than that of ^(99)Tc^(m)-MDP whole-body bone imaging(17.2±6.3μSv/h vs 5.7±4.9μSv/h,t=-9.278,P<0.001).After 24 hours,the radiation dose rates of the two imaging methods were similar,and the difference was not statistically significant(0.5±0.3μSv/h vs 0.6±0.3μSv/h,t=1.653,P=0.102).Conclusion Compared with ^(99)Tc^(m)-MDP whole-body bone imaging,18 F-NaF whole-body bone imaging shortens the waiting time for examination,and shows a higher image quality and consistency of scoring.In addition,the radiation dose rate of 24 hours after examination of the two imaging agents is similar.

关 键 词：^(99)Tc^(m)-亚甲基二膦酸盐 氟化钠 全身骨显像 辐射剂量率 

分 类 号：R692[医药卫生—泌尿科学]