血清IMA、Gal-3与急性ST段抬高型心肌梗死合并HFpEF患者PCI术后心源性猝死的关系研究  

Study on the Relationship between Serum IMA,Gal-3 and Sudden Cardiac Death after PCI in Patients with Acute ST-Segment Elevation Myocardial Infarction Complicated with HFpEF

作　　者：张赞伟 赵伟 金龙 马宏恩 许淑娣 ZHANG Zan-wei;ZHAO Wei;JIN Long;MA Hong-en;XU Shu-di(Department of Internal Medicine-Cardiovascular,Xi'an Ninth Hospital,Xi'an,Shaanxi,710054,China)

机构地区：[1]西安市第九医院心血管内科,陕西西安710054

出　　处：《现代生物医学进展》2024年第23期4474-4476,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81673787)。

摘　　要：目的:探讨血清缺血修饰白蛋白(IMA)、半乳糖凝集素-3(Gal-3)与急性ST段抬高型心肌梗死(STEMI)合并射血分数保留型心力衰竭(HFpEF)患者经皮冠状动脉介入(PCI)术后心源性猝死的关系。方法:205例行PCI术的急性STEMI合并HFpEF患者术后随访1年,随访期内45例发生心源性猝死纳入研究组,160例未发生心源性猝死纳入对照组。比较两组患者PCI术前血清IMA、Gal-3水平。多因素Logistic回归分析患者PCI术后心源性猝死的影响因素。结果:相比于对照组,研究组PCI术前血清IMA、Gal-3水平更高(均P<0.05)。多因素Logistic回归分析显示,术前血清IMA水平升高、Gal-3水平升高、多支血管病变、心功能Killip分级为IV级是急性STEMI合并HFpEF患者PCI术后发生心源性猝死的独立危险因素(P<0.05)。结论:血清IMA、Gal-3水平升高是急性STEMI合并HFpEF患者PCI术后发生心源性猝死的危险因素。Objective:To investigate the relationship between serum ischemia modified albumin(IMA),galectin-3(Gal-3)and sudden cardiac death after percutaneous coronary intervention(PCI)in patients with acute ST-segment elevation myocardial infarction(STEMI)complicated with heart failure with preserved ejection fraction(HFpEF).Methods:205 patients with acute STEMI complicated with HFpEF who underwent PCI were followed up for 1 year,45 patients with sudden cardiac death were included in the study group,and 160 patients without sudden cardiac death were included in the control group during the follow-up period.The levels of serum IMA and Gal-3 before PCI were compared between two groups.The influencing factors of sudden cardiac death after PCI were analyzed by multivariate Logistic regression analysis.Results:Compared with control group,the levels of serum IMA and Gal-3 in study group before PCI were higher(all P<0.05).Multivariate Logistic regression analysis showed that,elevated preoperative serum IMA level,elevated Gal-3 level,multi-vessel disease,and cardiac function Killip grade IV were independent risk factors for sudden cardiac death in patients with acute STEMI complicated with HFpEF after PCI(P<0.05).Conclusion:Elevated serum IMA and Gal-3 levels are risk factors for sudden cardiac death in patients with acute STEMI complicated with HFpEF after PCI.

关 键 词：急性ST段抬高型心肌梗死 射血分数保留型心力衰竭 缺血修饰白蛋白 半乳糖凝集素-3 经皮冠状动脉介入 心源性猝死 

分 类 号：R542.22[医药卫生—心血管疾病]