不同剂量替勃龙联合氨基酸螯合钙对绝经后骨质疏松的骨折预防作用及血清骨代谢指标、脂肪因子的影响  

Effects of Different Doses of Tibolone Combined with Calcium Amino Acid Chelate on Bone Fracture Prevention,Serum Bone Metabolism Indexes and Adipokines in Postmenopausal Osteoporosis

作　　者：王雨凡 苗天翼 张垚 王婉娟 倪丹红 WANG Yu-fan;MIAO Tian-yi;ZHANG Yao;WANG Wan-juan;NI Dan-hong(Department of Pharmacy,Northwest Women's and Children's Hospital,Xi'an,Shaanxi,710061,China;Department of Pharmacy,Shaanxi Provincial People's Hospital,Xi'an,Shaanxi,710068,China;Department of Pharmacy,Xi'an Fifth Hospital(Shaanxi Provincial Hospital of Integrated Traditional and Western Medicine),Xi'an,Shaanxi,710000,China)

机构地区：[1]西北妇女儿童医院药剂科,陕西西安710061 [2]陕西省人民医院药学部,陕西西安710068 [3]西安市第五医院(陕西省中西医结合医院)药剂科,陕西西安710000

出　　处：《现代生物医学进展》2024年第23期4480-4482,4486,共4页Progress in Modern Biomedicine

基　　金：陕西省创新能力支撑计划项目(2020KRM033)。

摘　　要：目的:探讨不同剂量替勃龙联合氨基酸螯合钙对绝经后骨质疏松的骨折预防作用及血清骨代谢指标、脂肪因子的影响。方法:选择2020.1-2023.1来我院诊治的绝经后骨质疏松96例,分为A组、B组、C组,各32例。三组均治疗6个月,并对比相关指标。结果:随访期间三组骨折发生率对比无差异(P>0.05)。治疗后,骨折组与非骨折组的骨密度、血清CRTP3水平上升,骨代谢水平降低,且非骨折组变化幅度明显较骨折组高(P<0.05)。三组治疗后骨密度水平、血清CRTP3升高,骨代谢指标降低,且B组、C组变化幅度较A组高(P<0.05),但B、C组间对比无差异(P>0.05)。不良反应发生率A组<B组<C组(P>0.05)。结论:低剂量替勃龙联合氨基酸螯合钙对绝经后骨质疏松患者有较好的骨折预防,且应用安全。Objective:To investigate the effects of different doses of Tibolone combined with calcium amino acid chelate on bone fracture prevention,serum bone metabolism indexes and adipokines in postmenopausal osteoporosis.Methods:96 cases of postmenopausal osteoporosis selected 2020.1-2023.1 to our hospital,divided into group A,B and C,with 32 cases each.All three groups were treated for 6 months,and relevant indicators were compared.Results:There was no difference in the three groups during follow-up(P>0.05).After treatment,bone density and serum CRTP 3 levels increased in the fracture group and the non-fracture group,while bone metabolism decreased,and the range of change in the non-fracture group was higher than that in the fracture group(P<0.05).After the three groups,bone density level and serum CRTP 3 increased,bone metabolism index decreased,and the range of change in group B and C was higher than that in group A(P<0.05),but there was no difference between groups B and C(P>0.05).Incidence of adverse reactions group A<B<C(P>0.05).Conclusion:Low dose tibolone combined with calcium amino acid chelate has better fracture prevention in postmenopausal osteoporosis patients,and the application is safe.

关 键 词：替勃龙 氨基酸螯合钙 绝经后骨质疏松 

分 类 号：R593.6[医药卫生—内科学]