八珍益母胶囊辅助治疗对药物流产后阴道出血患者血液流变学及性激素水平的影响  

Effects of Bazhen Yimu Capsule Adjuvant Therapy on Hemorheology and Sex Hormone Levels in Patients with Vaginal Bleeding after Medical Abortion

作　　者：谭惠简 冯翠仪 杨亚军 刘妙雯 林素芬 冯冰冰 TAN Hui-jian;FENG Cui-yi;YANG Ya-jun;LIU Miao-wen;LIN Su-fen;FENG Bing-bing(Department of Pharmacy,Shunde Women and Children's Hospital of Guangdong Medical University,Foshan,Guangdong,528300,China;Department of Gynecology,Shunde Women and Children's Hospital of Guangdong Medical University,Foshan,Guangdong,528300,China;School of Pharmacy,Guangdong Medical University,Zhanjiang,Guangdong,524023,China;Department of Pharmacy,Affiliated Hospital of Guangdong Medical University,Zhanjiang,Guangdong,524001,China)

机构地区：[1]广东医科大学顺德妇女儿童医院药学部,广东佛山528300 [2]广东医科大学顺德妇女儿童医院妇科,广东佛山528300 [3]广东医科大学药学院,广东湛江524023 [4]广东医科大学附属医院药学部,广东湛江524001

出　　处：《现代生物医学进展》2024年第23期4487-4489,共3页Progress in Modern Biomedicine

基　　金：2022年度广东省中医药局中医药科研项目(20222217);2023年佛山市自筹经费类科技创新项目(2320001007142)。

摘　　要：目的:探讨八珍益母胶囊辅助治疗药物流产后阴道出血的临床疗效及对患者血液流变学及性激素水平的影响,以期为药物流产后阴道出血患者临床治疗提供参考依据。方法:94例药物流产阴道出血患者采用随机化数字表法对94例患者进行分组,每组各47例。对照组予以缩宫素注射液联合肾上腺色腙片治疗,观察组在对照组基础上加用八珍益母胶囊,观察两组治愈率,记录临床症状好转时间,观测两组干预前后红细胞压积(HCT)、血浆黏度(PV)、全血黏度(BV)、血沉(ESR)等血液流变学指标水平变化,检测两组干预前后人绒毛膜促性腺激素(hCG)、雌二醇(E2)、孕酮(P)性激素指标水平变化,统计两组不良反应发生情况并比较发生率。结果:观察组治愈率较对照组高(P<0.05);观察组阴道出血持续时间、月经恢复时间及经期持续时间较对照组短(P<0.05);干预后观察组HCT、PV、BV、ESR水平水平较对照组低(P<0.05);干预后观察组hCG、P水平较对照组低,E2水平较对照组高(P<0.05);两组不良反应发生率无明显差异(P>0.05)。结论:八珍益母胶囊辅助治疗药物流产阴道出血疗效确切,不仅可稳定患者机体血液流变学,同时还能改善患者性激素水平,有效缩短阴道出血时间,促进病情好转,且安全性较高。Objective:To investigate the clinical efficacy of Bazhen Yimu capsule in the adjuvant treatment of postoperative vaginal bleeding after medical abortion and the effects on hemorheology and sex hormone levels,in order to provide reference for the clinical treatment of postoperative vaginal bleeding after medical abortion.Methods:A total of 94 patients with vaginal bleeding from medical abortion were divided into groups by randomized number table method,with 47 patients in each group.The control group was treated with oxytocin injection combined with carbazochrome tablets,while the observation group was treated with Bazhen Yimu capsule on the basi s of the control group.The cure rate of the two groups was observed,the improvement time of clinical symptoms was recorded,and the changes of hemorheological indexes such as hematocrit(HCT),plasma viscosity(PV),Blood Viscosity(BV),and erythrocyte sedimentation rate(ESR)before and after intervention were observed.The changes of human chorionic gonadotropin(hCG),estradiol(E2),progesterone(P)sex hormone indexes before and after intervention were detected in the two groups,and the occurrence of adverse reactions in the two groups were analyzed and the incidence rate was compared.Results:The cure rate of observation group was higher than control group(P<0.05).The duration of vaginal bleeding,menstrual recovery time and menstrual duration time in observation group were shorter than those in control group(P<0.05).After intervention,the HCT,PV,BV and ESR levels in the observation group were lower than those in the control group(P<0.05).After intervention,the levels of hCG and P in observation group were lower than those in control group,and the levels of E2 were higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Bazhen Yimu capsule has a definite effect on the adjuvant treatment of vaginal bleeding after medical abortion,which can not only stabilize the hemorheology of pati

关 键 词：八珍益母胶囊 药物流产 阴道出血 血液流变学 性激素水平 

分 类 号：R714.21[医药卫生—妇产科学]