腺苷脱氨酶、降钙素原、中性粒细胞与淋巴细胞比值对儿童肺炎病原体诊断的价值及与危重程度的关系分析  

Analysis of the Value of Adenosine Deaminase,Calcitoninogen,and Neutrophil-to-lymphocyte Ratio for the Diagnosis of Pneumonia Pathogens in Children and Their Relation to the Degree of Criticality

作　　者：马歆花 杨艳娥[1] 李兆坤 耿宝宝 杨妮 MA Xin-hua;YANG Yan-e;LI Zhao-kun;GENG Bao-bao;YANG Ni(Department of Pediatrics,The Second Affiliated Hospital of Xi'an Medical University,Xi'an,Shaanxi,710038,China)

机构地区：[1]西安医学院第二附属医院儿科,陕西西安710038

出　　处：《现代生物医学进展》2024年第23期4513-4515,共3页Progress in Modern Biomedicine

基　　金：陕西省重点研发计划项目(S2020-YF-YBSF-0597)。

摘　　要：目的:分析腺苷脱氨酶(ADA)、降钙素原(PCT)、中性粒细胞与淋巴细胞比值(NLR)对儿童肺炎病原体诊断的价值及与危重程度的关系。方法:选择我院自2023年1月至2024年1月收治的120例肺炎患儿纳入研究对象,根据感染的病原体类型分为细菌性肺炎组(55例)、病毒性肺炎组(39例)和支原体肺炎组(26例),检测相关指标。结果:三组ADA、PCT表达及NLR有差异(P<0.05);经ROC曲线分析,ADA、PCT联合NLR诊断细菌性肺炎、病毒性肺炎和支原体肺炎的AUC分别为0.812、0.803、0.789;重度肺炎患儿血清ADA、PCT水平均高于非重度肺炎患儿(P<0.05);经Pearson相关性分析,肺炎患儿血清ADA、PCT水平均与PCIS评分呈负相关(P<0.05),与PSI评分呈正相关(P<0.05)。结论:ADA、PCT联合NLR对儿童肺炎病原体诊断具有一定提示作用,其中ADA、PCT与患儿病情危重程度密切相关,值得临床予以重视应用。Objective:The value of adenosine deaminase(ADA),procalcitonin(PCT),neutrophil to lymphocyte ratio(NLR)in the diagnosis of pediatric pneumonia pathogens and its relationship with critical severity were analyzed.Methods:120 children with pneumonia admitted to our hospital from January 2023 to January 2024 were selected for the study.According to the types of infected pathogens,they were divided into bacterial pneumonia group(55 cases),viral pneumonia group(39 cases)and mycoplasma pneumonia group(26 cases),and relevant indicators were tested.Results:ADA,PCT and NLR expression were different among three groups(P<0.05);AUC of bacterial pneumonia,viral pneumonia and mycoplasma pneumonia were 0.812,0.803 and 0.789,respectively;serum ADA and PCT levels of children with severe pneumonia were higher than those of children without severe pneumonia(P<0.05);by Pearson correlation analysis,serum ADA and PCT levels in children with pneumonia were negatively correlated with PCIS score(P<0.05),positively associated with PSI score(P<0.05).Conclusion:ADA,PCT and NLR have a certain role in the diagnosis of pneumonia pathogens in children,among which ADA and PCT are closely related to the critical degree of children,which deserves clinical application.

关 键 词：儿童肺炎 腺苷脱氨酶 降钙素原 中性粒细胞与淋巴细胞比值 

分 类 号：R725.6[医药卫生—儿科]