温肺通痹汤联合甲泼尼龙对间质性肺疾病患者肺功能、血清KL-6、HMGB-1、IL-18水平及生活质量的影响  

Effects of Wenfei Tongbi Decoction Combined with Methylprednisolone on Lung Function,Serum KL-6,HMGB-1,IL-18 Levels and Quality of Life in Patients with Interstitial Lung Disease

作　　者：王婧 韩林华[2] 鞠秋燕[2] 周婷婷 胡涛 WANG Jing;HAN Lin-hua;JU Qiu-ya;ZHOU Ting-ting;HU Tao(Yangzhou University School of Medicine,Yangzhou,Jiangsu,225012,China;Department of Pulmonary Disease,Rugao Traditional Chinese Medicine Hospital,Rugao,Jiangsu,226500,China;Respiratory and Critical Care Medicine,Yangzhou University Affiliated Hospital,Yangzhou,Jiangsu,225012,China)

机构地区：[1]扬州大学医学院,江苏扬州225012 [2]如皋市中医院肺病科,江苏如皋226500 [3]扬州大学附属医院呼吸与危重症医学科,江苏扬州225012

出　　处：《现代生物医学进展》2024年第23期4587-4591,共5页Progress in Modern Biomedicine

基　　金：江苏省科学技术厅计划项目(BE2016710)。

摘　　要：目的:探讨温肺通痹汤联合甲泼尼龙对间质性肺疾病(ILD)患者肺功能、血清涎液化糖链抗原-6(KL-6)、高迁移率族蛋白-1(HMGB-1)、白细胞介素-18(IL-18)水平及生活质量的影响。方法:按随机数表法将如皋市中医院2022年2月~2023年12月期间收治的91例ILD患者分为对照组(甲泼尼龙治疗,n=45例)和观察组(温肺通痹汤联合甲泼尼龙治疗,n=46例)。对比两组疗效、临床症状的改善时间、肺功能指标[第1秒用力呼气容积(FEV1)、一氧化碳弥散量占预计值百分比(DLco%)、用力肺活量(FVC)]、血清KL-6、HMGB-1、IL-18水平、圣乔治呼吸问卷(SGRQ)评分和安全性。结果:与对照组相比,观察组治疗后呼吸困难、咳嗽、干湿啰音等临床症状、体征的改善时间更短,总有效率更高(P<0.05)。与对照组相比,观察组治疗后FVC、FEV1、DLco%更高,血清KL-6、HMGB-1、IL-18水平、SGRQ评分更低(P<0.05)。对照组总不良反应发生率为6.66%,观察组为8.69%,组间无差异(P>0.05)。结论:温肺通痹汤联合甲泼尼龙治疗ILD,可促进患者临床症状和肺功能的改善,调节血清KL-6、HMGB-1、IL-18水平,提高患者的生活质量。Objective:To investigate the effects of wenfei tongbi decoction combined with methylprednisolone on lung function,serum salivary liquefied sugar chain antigen-6(KL-6),high mobility group protein-1(HMGB-1),interleukin-18(IL-18)levels and quality of life in patients with interstitial lung disease(ILD).Methods:According to the random number table method,91 ILD patients admitted to Rugao Traditional Chinese Medicine Hospital from February 2022 to December 2023 were divided into control group(methylprednisolone treatment,n=45 cases)and observation group(wenfei tongbi decoction combined with methylprednisolone treatment,n=46 cases).The curative effect,the improvement time of clinical symptoms,lung function indexes[forced expiratory volume in the first second(FEV1),carbon monoxide diffusion volume as a percentage of predicted value(D Lco%),forced vital capacity(FVC)],serum KL-6,HMGB-1,IL-18 levels,St.George's Respiratory Questionnaire(SGRQ)score and safety were compared between two groups.Results:Compared with control group,the improvement time of clinical symptoms and signs such as dyspnea,cough,dry and wet rales in observation group after treatment was shorter,and the total effective rate was higher(P<0.05).Compared with control group,FVC,FEVi and DLco%were higher in observation group after treatment,and serum KL-6,HMGB-1,IL-18 levels and SGRQ scores were lower(P<0.05).The total incidence of adverse reactions in control group was 6.66%,and that in observation group was 8.69%,which was no difference between the two groups(P>0.05).Conclusion:Wenfei tongbi decoction combined with methylprednisolone in the treatment of ILD,which can promote the improvement of clinical symptoms and lung function,regulate the levels of serum KL-6,HMGB-1 and IL-18,and improve the quality of life of patients.

关 键 词：温肺通痹汤 甲泼尼龙 间质性肺疾病 肺功能 涎液化糖链抗原-6 高迁移率族蛋白-1 白细胞介素-18 生活质量 

分 类 号：R563.13[医药卫生—呼吸系统]