慢性鼻窦炎患者合高反应的多因素调查分析  

Multivariate investigation and analysis of airway hyperresponsiveness in patients with chronic sinusitis

作　　者：刘字 吴仕党 李鑫 梁建华 陆莎 吴博文 Liu Zi;Wu Shidang;Li Xin;Liang Jianhua;Lu Sha;Wu Bowen(Otolaryngology Department,Xiangzhou District People's Hospital,Zhuhai,Guangdong,519000,China)

机构地区：[1]珠海市香洲区人民医院,广东珠海519000

出　　处：《中国医学文摘（耳鼻咽喉科学）》2024年第6期122-125,共4页Chinese Medical Digest(Otorhinolaryngology)

基　　金：珠海市社会发展领域科技计划项目(项目编号:2320004000124)。

摘　　要：目的调查与分析慢性鼻窦炎(Chronic sinusitis,CRS)患者合并气道高反应(airway hyper-responsiveness,AHR)的发生因素,为预防气道高反应的发生提供参考。方法2023年1月到2024年3月选择在医院诊治的慢性鼻窦炎患者100例作为研究对象,判定气道高反应发生情况,调查患者的肺功能、一般资料与计数外周血嗜酸性粒细胞,分析气道高反应发生的影响因素。结果在100例患者中,判断为气道高反应阳性40例,占比40.00%。阳性组的第1秒用力呼气容积、用力肺活量、峰值呼气流速明显低于阴性组(P<0.05),阳性组的外周血嗜酸性粒细胞计数显著高于阴性组(P<0.05)。两组的性别、年龄、病程等对比无明显差异(P>0.05),阳性组的吸烟、鼻息肉、变应性鼻炎等与阴性组对比有显著性差异(P<0.05)。logistic回归分析显示外周血嗜酸性粒细胞计数、吸烟、鼻息肉、变应性鼻炎等为导致气道高反应阳性的重要因素(P<0.05)。结论慢性鼻窦炎患者合并气道高反应比较常见,且导致患者的肺功能下降,外周血嗜酸性粒细胞计数、吸烟、鼻息肉、变应性鼻炎等为导致气道高反应阳性的重要因素,要积极进行针对性干预。Objective To investigate and analyze the factors associated with airway hyper-responsiveness(AHR)in patients with chronic sinusitis(CRS),in order to provide reference for preventing the occurrence of AHR.Methods From January 2023 to March 2024,100 patients with chronic sinusitis who were treated in hospitals were selected as the research subjects.The occurrence of airway hyper-responsiveness was determined,and the patient's lung function,general information,and peripheral blood eosinophil count were investigated.The influencing factors of airway hyper-responsiveness were analyzed.Results Among the 100 patients,40 were diagnosed as positive for airway hyper-responsiveness,accounting for 40.00%.The first second forced expiratory volume,forced vital capacity,and peak expiratory flow rate of the positive group were significantly lower than those of the negative group(P<0.05).The peripheral blood eosinophil count in the positive group was significantly higher than that in the negative group(P<0.05).There was no significant difference in gender,age,and disease duration between the two groups(P>0.05).There were significant differences in smoking,nasal polyps,and allergic rhinitis between the positive group and the negative group(P<0.05).Logistic regression analysis showed that peripheral blood eosinophil count,smoking,nasal polyps,and allergic rhinitis were important factors leading to positive airway hyper-responsiveness(P<0.05).Conclusion It is common for patients with chronic sinusitis to have airway hyper-responsiveness,which can lead to a decrease in lung function.Peripheral blood eosinophil count,smoking,nasal polyps and allergic rhinitis are important factors that lead to positive airway hyper-responsiveness.Targeted interventions should be actively implemented.

关 键 词：慢性鼻窦炎 气道高反应 肺功能 嗜酸性粒细胞计数 鼻息肉、变应性鼻炎 

分 类 号：R76[医药卫生—耳鼻咽喉科]