Blackberry jam fruit(Randia formosa(Jacq.)K.Schum):An Amazon superfruit with in vitro neuroprotective properties  

作　　者：Giovanna Nascimento de Mello e Silva Edson Silvio Batista Rodrigues Isaac Yves Lopes de Macêdo Henric Pietro Vicente Gil Hericles Mesquita Campos Paulo César Ghedini Lidya Cardozo da Silva Erica Aparecida Batista Giovanna Lopes de Araújo Boniek Gontijo Vaz Tânia Aparecida Pinto de Castro Ferreira Renê Oliveira do Couto Eric de Souza Gil 

机构地区：[1]LAFAM – Laboratory for Pharmaceutical and Environmental Analysis,Faculdade de Farmácia,Universidade Federal de Goiás,Goiânia,Goiás,Brazil [2]DFar – Pharmacology Department,Instituto de Ciências Biológicas,Universidade Federal de Goiás,Goiânia,Goiás,Brazil [3]LaCEM – Laboratory of Chromatography and Mass Spectometry,Instituto de Química,Universidade Federal de Goiás,Goiânia,Goiás,Brazil [4]LANAL – Laboratory of Nutrition and Food Analysis,Faculdade de Nutrição,Universidade Federal de Goiás,Goiânia,Goiás,Brazil [5]Universidade Federal de São João del-Rei (UFSJ),Campus Centro-Oeste Dona Lindu (CCO),Divinópolis,Minas Gerais,Brazil

出　　处：《Food Bioscience》2022年第6期944-953,共10页食品生物科学（英文）

基　　金：financed in part by the Coordenaç˜ao de Aperfeiçoamento de Pessoal de Nível Superior-Brazil(CAPES)-Finance Code 001;We thank John Russell Carpenter(Djcingles Servicos em Lingua Inglesa-Ribeir˜ao Preto,SP,Brazil)for the English language revision;the Pro-Rectory of Research of the Federal University of S˜ao Jo˜ao del-Rei(PROPE/UFSJ)for the financial support provided(Edital nº010/2022/UFSJ/PROPE/Reitoria-Grant Aid for the Publication of Scientific Texts).

摘　　要：We report on the bromatological profile,the preliminary phytochemical composition,the antioxidant capacity,and the in vitro neuroprotective effects of Blackberry Jam fruit.Carbohydrates were the major macronutrients(20 g/100 g)in both pulp and seeds(36.5 g/100g),that also possess a low lipid content(0.1 g/100 g and 0.7 g/100,and 86 Kcal/100 g,respectively).Eleven compounds including a diterpenoid dimmer,a lactone,coumarins,sphingosines,and flavonoids have been identified for the first time in the pulp and seeds of R.formosa by mass spectrometry.The electrochemical index of the hydroalcoholic extract of the pulp(BJFp respectively)and an appreciable energy value(89 Kcal/100 g)was around 6.8μA/V and two reversible cathode peaks were observed up to 0.5 V,thus shedding light to its antioxidant capacity,which was also evidenced by the DPPH•and ABTS+radical scavenging assays(IC50 of 3.30±0.23μg/mL and 18.17±1.21μg/mL,respectively).The BJFp protected against oxidative stress in vitro by significantly decreasing both the lipid peroxidation and contents of carbonyl proteins in a dose-dependent manner in murine brain cells treated with H_(2)O_(2).Conversely,the BJFp increased the superoxide dismutase(EC50 of 11.99±0.35μg/mL)and catalase(EC_(50) of 69.53±0.43μg/mL)activities.The BJFp markedly decreased both the in vitro acetylcholinesterase(IC50 of 227.9±0.34μg/mL)and butyrylcholinesterase(IC_(50) of 8.77±0.40μg/mL)activities.Therefore,besides being a great source of energy,this Amazon superfruit may be promising for enhancing the treatment outcomes of ailments related to oxidative stress,which require further in vivo investigation.

关 键 词：ANTIOXIDANTS Cholinesterase inhibitors ELECTROCHEMISTRY Functional foods Phenolic compounds 

分 类 号：O62[理学—有机化学]