阿扎胞苷治疗难治性急性髓系白血病继发皮肌炎1例并文献复习  

Treatment of dermatomyositis secondary to refractory acute myelogenous leukemia with azacitidine:a case report and literature review

作　　者：沈继春 穆娟[2] Shen Jichun;Mu Juan(Department of Endocrinology and Hematology of the Characteristic Medical Center of Chinese People's Armed Plice Force,Tianjin 300162,China;Department of Hematology,the First Central Hospital of Tianjin,Tianjin 300110,China)

机构地区：[1]武警部队特色医学中心内分泌与血液科,天津300162 [2]天津市第一中心医院血液科,天津300110

出　　处：《中国综合临床》2024年第6期433-436,共4页Clinical Medicine of China

摘　　要：患者女性, 60岁。确诊为急性髓系白血病(acute myeloid leukemia, AML)。阿扎胞苷作为DNA转移酶抑制剂可治疗急性髓系白血病。该患者经阿扎胞苷治疗后, 颜面部皮肤出现多处红色丘疹, 经病变组织活检病理证实为皮肌炎。阿扎胞苷在治疗骨髓增生异常综合征(myelodysplastic syndrome, MDS)及急性髓系白血病的过程中可能会诱发皮肌炎, 但经激素及免疫抑制治疗后, 皮肌炎消失。The patient was a 60-year-old female.Acute myelogenous leukemia(AML)was diagnosed.Azacytidine acts as a DNA transferase inhibitor can treat acute myelogenous leukemia.After treatment with azacitidine,the patient developed multiple red papules on the facial skin,which were pathologically confirmed as dermatomyositis.Dermatomyositis may be induced by azacitidine in the treatment of myelodysplastic syndrome(MDS)and acute myelogenous leukemia,but the dermatomyositis will disappear after hormonal and immunosuppressive therapy.

关 键 词：阿扎胞苷 急性髓系白血病 皮肌炎 

分 类 号：R593.26[医药卫生—内科学] R733.71[医药卫生—临床医学]