孕中期低水平胎盘生长因子的表达与病理产科的关系  

Relationship between the expression of low-level placental growth factor in the second trimester of pregnancy and pathological obstetrics

作　　者：韩肖燕[1] 杨桦[1] Han Xiaoyan;Yang Hua(Department of Gynecology and Obstetrics,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院妇产科,北京100050

出　　处：《中国综合临床》2024年第6期443-446,共4页Clinical Medicine of China

摘　　要：目的研究孕中期胎盘生长因子(placenta growth factor, PLGF)低水平表达与病理产科的相关性。方法纳入2023年3月至2024年5月首都医科大学附属北京友谊医院产科规律产检并分娩的177例产妇的临床资料。其中, 孕中期PLGF低水平者共87例, 同时随机选取90名PLGF正常的产妇作为PLGF正常组, 比较两组病理产科结局的差异。正态分布的计量资料以xˉ±s表示, 两组间均数比较采用独立样本t检验;计数资料计算百分率, 两组间率的比较采用χ^(2)检验。P<0.05为差异有统计学意义。结果 PLGF低水平组产妇子痫前期的发生率为13.79%(12/87), PLGF正常组仅为2.22%(2/90), 组间差异有统计学意义(χ^(2)=8.13, P=0.004)。87例PLGF低水平产妇中, 孕期发生胎儿生长受限10例(11.49%), 早产11例(12.64%);与同期PLGF正常组胎儿生长受限发生率3.33%(3/90), 早产发生率3.33%(3/90)相比, PLGF低水平组胎儿生长受限及早产发生率明显升高, 组间差异均有统计学意义(χ^(2)=4.33, P=0.037;χ^(2)=5.26, P=0.022)。PLGF低水平胎儿窘迫发生率为10.34%(9/87), PLGF正常组为4.44%(4/90), 两组间胎儿窘迫的发生率比较差异无统计学意义(χ^(2)=2.26, P=0.132)。PLGF低水平组有3例(3.45%, 3/87)发生胎盘早剥, PLGF正常组仅1例(1.11%, 1/90)发生, 虽然PLGF组胎盘早剥的发生率高于PLGF正常组, 但组间差异无统计学意义(χ^(2)=0.29, P=0.589)。结论孕中期PLGF水平的降低与子痫前期、胎儿生长受限及早产发生有关。ObjectiveTo study the relationship between the low expression of placenta growth factor(PLGF)in the second trimester of pregnancy and obstetrics pathology.MethodsA total of 177 cases of pregnant women in the second-trimester who received regular prenatal checkups in the Department of Obstetrics,Beijing Friendship Hospital,Capital Medical University from March 2023 to May 2024 were selected as research subjects.Among them,87 cases expressed low level of PLGF;90 cases with normal PLGF were randomly selected as the control group.The measurement data of normal distribution were expressed as x¯±s,the comparison of mean between two groups was performed by independent sample t-test,the percentage was calculated by counting data,and the comparison of rates between two groups was performed byχ^(2) test.P≤0.05 was statistically significant.Results The incidence of preeclampsia was 13.79%(12/87)in the low PLGF group and 2.22%(2/90)in the control group.There was significant difference between the two groups(χ^(2)=8.13,P=0.004).In 87 cases with low level of PLGF,there were 10 cases of fetal growth restriction and 11 cases of premature delivery during pregnancy.Compared with normal pregnancy group,the rate of fetal growth restriction and premature delivery in low level of PLGF group was significantly higher,there was significant difference between the two groups(χ^(2)=4.33,P=0.037;χ^(2)=5.26,P=0.022).The incidence of fetal distress in the PLGF low-level group was 10.34%(9/87),while the incidence of fetal distress in the PLGF normal group was 4.44%(4/90).There was no statistically significant difference in the incidence of fetal distress between the two groups(χ^(2)=2.26,P=0.132).In this study,3 cases(3.45%,3/87)of placental abruption occurred in the PLGF low-level group,while only 1 case(1.11%,1/90)occurred in the PLGF normal group.Although the incidence of placental abruption in the PLGF group was higher than that in the PLGF normal group,the difference between the groups was not statistically significant(χ^(2)=0.29

关 键 词：妊娠中期 胎盘生长因子 病理产科 

分 类 号：R714.2[医药卫生—妇产科学]