桑白皮汤熏蒸联合揿针治疗慢性阻塞性肺疾病急性加重期临床研究  

Clinical Study on Fumigation with Sangbaipi Decoction Combined with Thumbtack Needle for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：朱培琴 沈芬 杨通 ZHU Peiqin;SHEN Fen;YANG Tong(Health Administration Center,Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University,Huzhou Zhejiang 313000,China;Respiratory Department,Huzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University,Huzhou Zhejiang 313000,China)

机构地区：[1]浙江中医药大学附属湖州中医院治未病中心,浙江湖州313000 [2]浙江中医药大学附属湖州中医院呼吸科,浙江湖州313000

出　　处：《新中医》2024年第24期11-15,共5页New Chinese Medicine

基　　金：湖州市科学技术局资助项目(2019GY40)。

摘　　要：目的:观察桑白皮汤熏蒸联合揿治疗对慢性阻塞性肺疾病急性加重期(AECOPD)的临床效果。方法:选取80例AECOPD患者,按随机数字表法分为对照组与观察组各40例。对照组予以常规西医治疗,观察组在对照组基础上应用桑白皮汤熏蒸联合揿针治疗。治疗3个月,比较2组临床疗效、改良版英国医学研究委员会呼吸问卷评分(mMRC)、COPD评估测试评分(CAT)、肺功能[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC]、血清炎症因子[白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)]水平。结果:观察组总有效率95.00%,高于对照组77.50%,差异有统计学意义(P<0.05)。治疗后,2组FEV_(1)、FVC、FEV_(1)/FVC水平均较治疗前升高(P<0.05),观察组FEV_(1)、FVC、FEV_(1)/FVC水平均高于对照组(P<0.05)。治疗后,2组mMRC评分均较治疗前降低(P<0.05),且观察组mMRC评分低于对照组(P<0.05)。治疗后,2组CAT评分均较治疗前降低(P<0.05),且观察组CAT评分低于对照组(P<0.05)。治疗后,2组CRP、IL-8、TNF-α水平均较治疗前降低(P<0.05),且观察组CRP、IL-8、TNF-α水平均低于对照组(P<0.05)。结论:桑白皮汤熏蒸联合揿针治疗AECOPD疗效显著,可减轻临床症状,改善患者肺功能,其作用机制可能与下调炎症因子水平有关。Objective:To observe the therapeutic effect of fumigation with Sangbaipi Decoction combined with the thumbtack needle on acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 80 patients with AECOPD were selected and randomly divided into the control group and the observation group,with 40 patients in each group.The control group received conventional western medicine treatment,and the observation group was treated with fumigation with Sangbaipi Decoction combined with the thumbtack needle based on the treatment of the control group.After three months of treatment,the clinical effects,scores of modified British Medical Research Council(mMRC)and COPD Assessment Test(CAT),lung function[forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC),and FEV_(1)/FVC],and the levels of serum inflammatory factors[interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),and C-reactive protein(CRP)]were compared between the two groups.Results:The total effective rate was 95.00%in the observation group,which was higher than that of 77.50%in the control group,the difference being significant(P<0.05).After treatment,FEV_(1),FVC,and FEV_(1)/FVC in the two groups were increased when compared with those before treatment(P<0.05),and FEV_(1),FVC,and FEV_(1)/FVC in the observation group were higher than those in the control group(P<0.05).After treatment,the mMRC scores in the two groups were decreased when compared with those before treatment(P<0.05),and the mMRC scores in the observation group were lower than those in the control group(P<0.05).After treatment,the CAT scores in the two groups were decreased when compared with those before treatment(P<0.05),and the CAT scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of CRP,IL-8,and TNF-αin the two groups were decreased when compared with those before treatment(P<0.05),and the levels of CRP,IL-8,and TNF-αin the observation group were lower than those in the control group(P<0.05).

关 键 词：慢性阻塞性肺疾病急性加重期 桑白皮汤 熏蒸 揿针 肺功能 炎症因子 

分 类 号：R563[医药卫生—呼吸系统]