银杏酮酯滴丸联合阿司匹林肠溶片治疗冠心病稳定型心绞痛心血瘀阻证回顾性研究  

Retrospective Study on Yinxing Tongzhi Dripping Pills Combined with Aspirin Enteric-Coated Tablets for Stable Angina Pectoris of Coronary Heart Disease with Heart Blood Stasis Obstruction Syndrome

作　　者：王晶一 史振国 郁宇婷 WANG Jingyi;SHI Zhenguo;YU Yuting(Pharmacy Department,Ningbo Rehabilitation Hospital,Ningbo Zhejiang 315040,China;Department of Chinese Medicine,Ningbo Rehabilitation Hospital,Ningbo Zhejiang 315040,China)

机构地区：[1]宁波市康复医院药剂科,浙江宁波315040 [2]宁波市康复医院中医科,浙江宁波315040

出　　处：《新中医》2024年第24期41-45,共5页New Chinese Medicine

摘　　要：目的:回顾性研究银杏酮酯滴丸联合阿司匹林肠溶片治疗冠心病稳定型心绞痛心血瘀阻证的临床疗效及对心肌酶谱、血清学指标的影响。方法:选取2021年3月—2023年6月宁波市康复医院收治的82例冠心病稳定型心绞痛心血瘀阻证患者的临床资料,依据不同治疗方式分为2组,每组41例。观察组给予银杏酮酯滴丸联合阿司匹林肠溶片治疗,对照组给予阿司匹林肠溶片治疗,2组均持续给药5周,比较2组中医证候积分、临床疗效,比较2组治疗前后心肌酶谱指标[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)]、氧化应激指标[超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)、丙二醛(MDA)、内皮素-1(ET-1)],以及成纤维细胞生长因子21(FGF21)、超敏C-反应蛋白(hs-CRP)的变化;比较2组不良反应发生情况。结果:治疗后,2组CK、CK-MB、LDH、α-HBDH水平均降低,观察组CK、CK-MB、LDH、α-HBDH水平均低于对照组,差异均有统计学意义(P<0.05);治疗后,2组SOD、T-AOC水平均高于治疗前,MDA、ET-1、FGF21、hs-CRP水平均低于治疗前,观察组SOD、T-AOC均高于对照组,MDA、ET-1、FGF21、hs-CRP均低于对照组,差异均有统计学意义(P<0.05)。观察组临床疗效及中医证候疗效总有效率均高于对照组,差异均有统计学意义(P<0.05)。观察组恶心、头痛头胀、头晕、皮疹、胃部不适等不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论:银杏酮酯滴丸联合阿司匹林肠溶片治疗冠心病稳定型心绞痛心血瘀阻证疗效良好,能降低心肌酶,减少氧化应激反应,改善临床症状,且具有一定安全性。Objective:To respectively study the clinical effect of the therapy of Yinxing Tongzhi Dripping Pills combined with Aspirin Enteric-Coated Tablets on stable angina pectoris of coronary heart disease with heart blood stasis obstruction syndrome and its effect on myocardial enzymes and orrhology indexes.Methods:A total of 82 patients with stable angina pectoris of coronary heart disease with heart blood stasis obstruction syndrome admitted to Ningbo Rehabilitation Hospital from March 2021 to June 2023 were selected as the study objects.According to different treatment methods,they were divided into two groups,with 41 cases in each group.The observation group was treated with Yinxing Tongzhi Dropping Pills combined with Aspirin Enteric-Coated Tablets,and the control group was treated with Aspirin Enteric-Coated Tablets.Both groups were treated for five weeks.The traditional Chinese medicine syndrome scores and clinical effects,the changes of myocardial enzyme indexes[creatine kinase(CK),creatine kinase MB(CK-MB),lactate dehydrogenase(LDH),α-hydroxybutyrate dehydrogenase(α-HBDH)],oxidative stress indexes[superoxide dismutase(SOD),total antioxidant capacity(T-AOC),malondialdehyde(MDA),and endothelin-1(ET-1)],fibroblast growth factor 21(FGF21)and high-sensitivity C-reactive protein(hs-CRP)before and after treatment,and the incidence of adverse reactions were respectively compared between the two groups.Results:After treatment,the levels of CK,CK-MB,LDH andα-HBDH in the two groups were dwindled,and the levels of CK,CK-MB,LDH andα-HBDH in the observation group were lower than those in the control group,differences being significant(P<0.05);after treatment,the levels of SOD and T-AOC in the two groups were higher than those before treatment,and the levels of MDA,ET-1,FGF21 and hs-CRP were lower than those before treatment;the levels of SOD and T-AOC in the observation group were higher than those in the control group,and the levels of MDA,ET-1,FGF21 and hs-CRP were lower than those in the control group,differences bein

关 键 词：冠心病稳定型心绞痛 心血瘀阻证 银杏酮酯滴丸 阿司匹林肠溶片 心肌酶谱 氧化应激 

分 类 号：R541.4[医药卫生—心血管疾病]