基于网络药理学探讨桑白皮汤治疗慢性支气管炎的潜在作用机制  

To explore the potential mechanism of Sangbaipi Decoction in treating chronic bronchitis based on network pharmacology

作　　者：苏宏悦 卓铭松 向晶 许光兰[1,2] SU Hongyue;ZHUO Mingsong;XIANG Jing(Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530001,China;不详)

机构地区：[1]广西中医药大学研究生院,南宁530001 [2]广西中医药大学第一附属医院呼吸与危重症医学科,南宁530023

出　　处：《中国处方药》2024年第12期20-26,共7页Journal of China Prescription Drug

摘　　要：目的基于网络药理学方法探讨桑白皮汤(SBPD)治疗慢性支气管炎的潜在作用机制。方法在TCMSP数据库检索SBPD的主要活性成分,利用PubChem数据库获取成分靶点,SwissTargetPrediction网站进行靶点预测,通过GeneCards、OMIM、TTD数据库获取慢性支气管炎的疾病靶点。对获取的交集靶点,利用String数据库构建蛋白质互作网络,通过微生信在线网站进行GO生物功能富集分析和KEGG通路富集分析。结果筛选得到SBPD的122个活性成分和948个靶点,慢性支气管炎疾病靶点1478个,两者交集后获得药物与疾病共有核心靶点210个。GO功能富集分析结果显示SBPD可涉及844条生物学过程、170项分子功能、98项细胞组成。KEGG通路富集分析得到182条信号通路,主要包括癌症相关通路、感染相关通路、TNF信号通路、IL-17信号通路等。结论SBPD治疗慢性支气管炎具有多成分、多靶点、多通路的网络化互作特点,可为进一步探究其作用机制提供理论依据。Objective To explore the potential mechanism of Sangbaipi Decoction(SBPD)in the treatment of chronic bronchitis based on network pharmacology.Methods The main active components of SBPD were searched in TCMSP database.The targets of components were obtained using PubChem and SwissTargetPrediction website was used for target prediction.GeneCards,OMIM and TTD databases were used to obtain the disease target of chronic bronchitis.For the obtained intersection targets,STRING database was used to construct a protein-protein interaction networks,and GO biological function enrichment analysis and KEGG pathway enrichment analysis were performed through the Microbiology Information online website.Results A total of 122 active components and 948 targets of SBPD were screened,1478 targets of chronic bronchitis disease were obtained.After the intersection of the two,210 core targets of drugs and diseases were obtained.GO functional enrichment analysis showed that SBPD could involve 844 biological processes,170 molecular functions,and 98 cellular compositions.KEGG pathway enrichment analysis obtained 182 signaling pathways,mainly including cancer-related pathways,infection-related pathways,TNF signaling pathways,and IL-17 signaling pathways.Conclusion SBPD has the characteristics of multi-component,multi-target and multi-pathway network interaction in the treatment of chronic bronchitis,which can provide a theoretical basis for further exploration of its mechanism of action.

关 键 词：桑白皮汤 中药复方 慢性支气管炎 作用机制 网络药理学 

分 类 号：R285[医药卫生—中药学]