某院儿童青少年精神障碍患者的抗抑郁药联用及超说明书用药现状调查分析  

Investigation on current situation of antidepressants combination and off-label drug use in adolescents with mental disorders in the hospital

作　　者：吕春龙 朱东漫 冯子桥 LV Chunlong;ZHU Dongman;FENG Ziqiao(Department of the Pharmacy,The Third People's Hospital of Zhanjiang Zhanjiang 524012,China;不详)

机构地区：[1]湛江市第三人民医院药剂科,广东湛江524012 [2]湛江市第三人民医院神经康复科,广东湛江524012

出　　处：《中国处方药》2024年第12期61-64,共4页Journal of China Prescription Drug

摘　　要：目的调查儿童青少年精神障碍患者的抗抑郁药联用及超说明书用药现状并进行分析。方法调查2023年1月~12月儿童青少年精神障碍患者的门诊处方,依据国家药品监督管理局药品说明书统计儿童青少年精神障碍患者抗抑郁药联用及超说明书用药现状。结果1644份抗抑郁处方中超说明书使用636份,超说明书使用率38.69%。1356份含抗抑郁药联合使用处方不合理联用300份,不合理联用率22.12%。超说明书用药中以“无儿童用药标识”最多,占比58.49%。不合理联用处方中以“存在可能产生不良后果的相互作用”最多,占比56.00%。不同年龄段患者超说明书用药率、含抗抑郁药联合使用处方不合理率比较,差异有统计学意义(P<0.05)。不同职称医师开具超说明书用药处方率、含抗抑郁药联合使用不合理处方率比较,差异有统计学意义(P<0.05)。结论儿童青少年精神障碍患者超说明书用药情况普遍存在,需要制定临床相关指南、专家共识规范用药,保障儿童青少年用药安全。Objective To investigate and analyze the current situation of antidepressants combination and off-label drug use in adolescents with mental disorders in the hospital.Methods The outpatient prescriptions from adolescents with mental disorders were investigated between January and December 2023.According to drug instructions from National Medical Products Administration,current situation of antidepressants combination and off-label drug use in adolescents with mental disorders was statistically analyzed.Results In the 1644 pieces of antidepressant prescriptions,there were and 636 pieces of off-label use,with off-label use rate of 38.69%.In the 1356 pieces of prescriptions containing antidepressants combination,there were 300 pieces(22.12%)with unreasonable combination.In off-label drug use,proportion of no drug labeling for children was the highest(58.49%).In irrational prescriptions,proportions of interaction that might cause adverse outcomes was the highest(56.00%).There were significant differences in off-label drug use rate and unreasonable rate of antidepressants combination among patients at different age groups(P<0.05).There were significant differences in prescription rates of off-label drug use and unreasonable prescription rate of antidepressants combination among physicians with different professional titles(P<0.05).Conclusion Off-label drug use is common in adolescents with mental disorders.It is necessary to formulate relevant clinical guidelines and expert consensus to standardize drug use so as to ensure medication safety of adolescents.

关 键 词：儿童青少年 精神障碍 抗抑郁药 联合用药 超说明书用药 

分 类 号：R971.43[医药卫生—药品]