某妇幼保健院静注人免疫球蛋白在生殖健康与不孕症科超说明书用药情况及其合理性评价  

Evaluation the use and its reasonableness of intravenous immunoglobulin in the department of reproductive health and infertility in a maternal and child health hospital

作　　者：杜薇 郑玉贵 叶晓萍 邓贵华[1] DU Wei;ZHENG Yugui;YE Xiaoping(Department of Pharmacy,Guangdong Women and Children Hospital,Guangzhou 511400,China)

机构地区：[1]广东省妇幼保健院药学部,广州511400

出　　处：《中国处方药》2024年第12期77-80,共4页Journal of China Prescription Drug

基　　金：中国药学会科技开发中心科普项目[CMEI2022KPYJ(ZAMM)00621]。

摘　　要：目的分析生殖健康与不孕症科(生殖科)住院患者应用静注人免疫球蛋白(IVIG)的合理性。方法回顾性分析2023年1~12月生殖科包含IVIG的医嘱153例,用Excel对医嘱中患者基本信息、临床诊断等数据进行汇总分析。参考药品说明书、临床指南、专家共识、相关文献判断用药合理性。结果纳入研究的153例使用IVIG的医嘱均为超说明书用药,其中超适应证用药排名前三的分别为免疫功能异常、复发性流产、抗磷脂综合征。经过循证医学评价后发现151例超说明书用药是合理的,2例不合理,用药合理率为98.7%。结论生殖科超说明书使用IVIG的情况普遍存在,大多数适应证有循证医学证据支持,但也存在少数不合理现象。Objective To analyze the rationality of intravenous immunoglobulin(IVIG)in inpatients of reproductive department.Methods A retrospective analysis was performed for 153 cases of IVIG in the department of reproductive health and infertility from January 2023 to December 2023.Excel was used to summarize and analyze the basic patient information,usage and dosage,clinical diagnosis and other data in the doctor's order.Refer to the instructions,relevant clinical guidelines at home and abroad,expert consensus,and literature to judge the rationality of the use.Results The 153 cases of IVIG were prescribed off-label medication,and the top three off-label indications were immune dysfunction,recurrent miscarriage,and antiphospholipid syndrome.After evidence-based medical evaluation,it was found that 151 cases of off-label medication were reasonable,and 2 cases were unreasonable,and the reasonable rate of medication was 98.7%.Conclusion The off-label use of IVIG in the department of reproductive health and infertility is widespread,and most of the indications are supported by evidence-based medical evidence,but there are also a few unreasonable phenomena.

关 键 词：静注人免疫球蛋白 生殖科 超说明书用药 合理性分析 

分 类 号：R95[医药卫生—药学]